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dc.contributor.authorBoltz, H. H.
dc.contributor.authorSirbu, A.
dc.contributor.authorStelzer, N.
dc.contributor.authorLohse, M. J.
dc.contributor.authorSchütte, C.
dc.contributor.authorAnnibale, P.
dc.date.accessioned2022-01-12T13:30:25Z
dc.date.available2022-01-12T13:30:25Z
dc.date.issued2021-04-01
dc.identifier277341877
dc.identifier5d3ed1c6-80ed-426d-b242-e315514873df
dc.identifier85102979258
dc.identifier33793480
dc.identifier.citationBoltz , H H , Sirbu , A , Stelzer , N , Lohse , M J , Schütte , C & Annibale , P 2021 , ' Quantitative spectroscopy of single molecule interaction times ' , Optics Letters , vol. 46 , no. 7 , pp. 1538-1541 . https://doi.org/10.1364/OL.413030en
dc.identifier.issn0146-9592
dc.identifier.otherORCID: /0000-0003-3208-5347/work/105957257
dc.identifier.urihttps://hdl.handle.net/10023/24651
dc.descriptionFunding Information: Deutsche Forschungsgemeinschaft (421152132 (subproject C03)), EXC 2046 (MATH+Incubator project IN-B2).en
dc.description.abstractSingle molecule fluorescence tracking provides information at nanometer-scale and millisecond-temporal resolution about the dynamics and interaction of individual molecules in a biological environment. While the dynamic behavior of isolated molecules can be characterized well, the quantitative insight is more limited when interactions between two indistinguishable molecules occur. We address this aspect by developing a theoretical foundation for a spectroscopy of interaction times, i.e., the inference of interaction from imaging data. A non-trivial crossover between a power law to an exponential behavior of the distribution of the interaction times is highlighted, together with the dependence of the exponential term upon the microscopic reaction affinity. Our approach is validated with simulated and experimental datasets.
dc.format.extent4
dc.format.extent2405327
dc.language.isoeng
dc.relation.ispartofOptics Lettersen
dc.subjectQC Physicsen
dc.subjectAtomic and Molecular Physics, and Opticsen
dc.subjectT-NDASen
dc.subjectMCCen
dc.subject.lccQCen
dc.titleQuantitative spectroscopy of single molecule interaction timesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.identifier.doi10.1364/OL.413030
dc.description.statusPeer revieweden


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