Files in this item
Rationalisation of patterns of competing reactivity by X-ray structure determination : reaction of isomeric (benzyloxythienyl)oxazolines with a base
Item metadata
dc.contributor.author | Aitken, R Alan | |
dc.contributor.author | Harper, Andrew D. | |
dc.contributor.author | Slawin, Alexandra M. Z. | |
dc.date.accessioned | 2021-12-21T12:30:14Z | |
dc.date.available | 2021-12-21T12:30:14Z | |
dc.date.issued | 2021-12-20 | |
dc.identifier | 277113485 | |
dc.identifier | f6ab0914-d32c-4ee0-aaad-cd120cd75c28 | |
dc.identifier | 85121633158 | |
dc.identifier | 000736750500001 | |
dc.identifier.citation | Aitken , R A , Harper , A D & Slawin , A M Z 2021 , ' Rationalisation of patterns of competing reactivity by X-ray structure determination : reaction of isomeric (benzyloxythienyl)oxazolines with a base ' , Molecules , vol. 26 , no. 24 , 7690 . https://doi.org/10.3390/molecules26247690 | en |
dc.identifier.issn | 1420-3049 | |
dc.identifier.other | ORCID: /0000-0002-9527-6418/work/105318188 | |
dc.identifier.other | ORCID: /0000-0001-6959-5311/work/105318322 | |
dc.identifier.uri | https://hdl.handle.net/10023/24550 | |
dc.description | Funding: We thank EPSRC (UK) for a DTA studentship to ADH (Grant EP/L505079/1) and the EPSRC UK National Mass Spectrometry Facility at Swansea University. | en |
dc.description.abstract | Three isomeric (benzyloxythienyl)oxazolines 9 , 11 and 13 have been prepared and are found, upon treatment with strong base, to undergo either Wittig rearrangement or intramolecular attack of the benzylic anion on the oxazoline function to give products derived from cleavage of the initially formed 3-aminothienofuran products. This pattern of reactivity is directly linked to the distance between the two reactive groups as determined by X-ray diffraction, with the greatest distance in 11 leading to exclusive Wittig rearrangement, the shortest distance in 13 giving exclusively cyclisation-derived products, and the intermediate distance in 9 leading to both processes being observed. The corresponding N-butyl amides were also obtained in two cases and one of these undergoes efficient Wittig rearrangement leading to a thieno[2,3-c]pyrrolone product. | |
dc.format.extent | 17 | |
dc.format.extent | 2680378 | |
dc.language.iso | eng | |
dc.relation.ispartof | Molecules | en |
dc.subject | Oxazolines | en |
dc.subject | Wittig rearrangement | en |
dc.subject | Thiophene | en |
dc.subject | Thieno[2,3-c]pyrrolone | en |
dc.subject | X-ray structure | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject.lcc | QD | en |
dc.title | Rationalisation of patterns of competing reactivity by X-ray structure determination : reaction of isomeric (benzyloxythienyl)oxazolines with a base | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | 10.3390/molecules26247690 | |
dc.description.status | Peer reviewed | en |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.