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dc.contributor.authorKillip, M. J.
dc.contributor.authorYoung, D. F.
dc.contributor.authorPrecious, B. L.
dc.contributor.authorGoodbourn, S.
dc.contributor.authorRandall, R. E.
dc.date.accessioned2012-03-16T13:01:05Z
dc.date.available2012-03-16T13:01:05Z
dc.date.issued2012-02
dc.identifier.citationKillip , M J , Young , D F , Precious , B L , Goodbourn , S & Randall , R E 2012 , ' Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis ' , Journal of General Virology , vol. 93 , no. 2 , pp. 299-307 . https://doi.org/10.1099/vir.0.037531-0en
dc.identifier.issn0022-1317
dc.identifier.otherPURE: 17784158
dc.identifier.otherPURE UUID: c94179de-4b4f-4506-bf2c-979a152cdc3c
dc.identifier.otherWOS: 000300139500009
dc.identifier.otherScopus: 84855945567
dc.identifier.otherORCID: /0000-0002-9304-6678/work/60427038
dc.identifier.urihttps://hdl.handle.net/10023/2451
dc.description.abstractConflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating the IFN-induction cascade are not normally generated during virus replication, but are associated instead with the presence of defective interfering (DI) viruses. We demonstrate here that DIs of paramyxoviruses, including parainfluenza virus 5, mumps virus and Sendai virus, can activate the IFN-induction cascade and the IFN-beta promoter in the absence of virus protein synthesis. As virus protein synthesis is an absolute requirement for paramyxovirus genome replication, our results indicate that these DI viruses do not require replication to activate the IFN-induction cascade.
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofJournal of General Virologyen
dc.rights(c)2012 SGM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectQR355 Virologyen
dc.subject.lccQR355en
dc.titleActivation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesisen
dc.typeJournal articleen
dc.contributor.sponsorThe Wellcome Trusten
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1099/vir.0.037531-0
dc.description.statusPeer revieweden
dc.identifier.grantnumber087751/A/08/Zen


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