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Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis
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dc.contributor.author | Killip, M. J. | |
dc.contributor.author | Young, D. F. | |
dc.contributor.author | Precious, B. L. | |
dc.contributor.author | Goodbourn, S. | |
dc.contributor.author | Randall, R. E. | |
dc.date.accessioned | 2012-03-16T13:01:05Z | |
dc.date.available | 2012-03-16T13:01:05Z | |
dc.date.issued | 2012-02 | |
dc.identifier.citation | Killip , M J , Young , D F , Precious , B L , Goodbourn , S & Randall , R E 2012 , ' Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis ' , Journal of General Virology , vol. 93 , no. 2 , pp. 299-307 . https://doi.org/10.1099/vir.0.037531-0 | en |
dc.identifier.issn | 0022-1317 | |
dc.identifier.other | PURE: 17784158 | |
dc.identifier.other | PURE UUID: c94179de-4b4f-4506-bf2c-979a152cdc3c | |
dc.identifier.other | WOS: 000300139500009 | |
dc.identifier.other | Scopus: 84855945567 | |
dc.identifier.other | ORCID: /0000-0002-9304-6678/work/60427038 | |
dc.identifier.uri | https://hdl.handle.net/10023/2451 | |
dc.description.abstract | Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating the IFN-induction cascade are not normally generated during virus replication, but are associated instead with the presence of defective interfering (DI) viruses. We demonstrate here that DIs of paramyxoviruses, including parainfluenza virus 5, mumps virus and Sendai virus, can activate the IFN-induction cascade and the IFN-beta promoter in the absence of virus protein synthesis. As virus protein synthesis is an absolute requirement for paramyxovirus genome replication, our results indicate that these DI viruses do not require replication to activate the IFN-induction cascade. | |
dc.format.extent | 9 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of General Virology | en |
dc.rights | (c)2012 SGM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.subject | QR355 Virology | en |
dc.subject.lcc | QR355 | en |
dc.title | Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis | en |
dc.type | Journal article | en |
dc.contributor.sponsor | The Wellcome Trust | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1099/vir.0.037531-0 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | 087751/A/08/Z | en |
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