Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis
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Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating the IFN-induction cascade are not normally generated during virus replication, but are associated instead with the presence of defective interfering (DI) viruses. We demonstrate here that DIs of paramyxoviruses, including parainfluenza virus 5, mumps virus and Sendai virus, can activate the IFN-induction cascade and the IFN-beta promoter in the absence of virus protein synthesis. As virus protein synthesis is an absolute requirement for paramyxovirus genome replication, our results indicate that these DI viruses do not require replication to activate the IFN-induction cascade.
Killip , M J , Young , D F , Precious , B L , Goodbourn , S & Randall , R E 2012 , ' Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis ' Journal of General Virology , vol 93 , no. 2 , pp. 299-307 . DOI: 10.1099/vir.0.037531-0
Journal of General Virology
(c)2012 SGM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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