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dc.contributor.authorFinlayson, Louise
dc.contributor.authorBarnard, Isla R.M.
dc.contributor.authorMcMillan, Lewis
dc.contributor.authorIbbotson, Sally H.
dc.contributor.authorBrown, C. Tom A.
dc.contributor.authorEadie, Ewan
dc.contributor.authorWood, Kenneth
dc.identifier.citationFinlayson , L , Barnard , I R M , McMillan , L , Ibbotson , S H , Brown , C T A , Eadie , E & Wood , K 2022 , ' Depth penetration of light into skin as a function of wavelength from 200 nm to 1000 nm ' , Photochemistry and Photobiology , vol. 98 , no. 4 , pp. 974-981 .
dc.identifier.otherRIS: urn:396E81E5A1F1905D63554B652C74446A
dc.identifier.otherORCID: /0000-0002-4405-6677/work/103510827
dc.identifier.otherORCID: /0000-0002-7725-5162/work/103511102
dc.descriptionLouise Finlayson acknowledges financial support from EPSRC Industrial Doctorate Centre Scheme (2262922) and the Laser Research and Therapy Fund (registered charity SC030850).en
dc.description.abstractAn increase in the use of light-based technology and medical devices has created a demand for informative and accessible data showing the depth that light penetrates into skin and how this varies with wavelength. These data would be particularly beneficial in many areas of medical research and would support the use and development of disease-targeted light-based therapies for specific skin diseases, based on increased understanding of wavelength-dependency of cutaneous penetration effects. We have used Monte Carlo radiative transport (MCRT) to simulate light propagation through a multi-layered skin model for the wavelength range of 200 nm – 1000 nm. We further adapted the simulation to compare the effect of direct and diffuse light sources, varying incident angles and stratum corneum thickness. The lateral spread of light in skin was also investigated. As anticipated, we found that the penetration depth of light into skin varies with wavelength in accordance with the optical properties of skin. Penetration depth of ultraviolet radiation was also increased when the stratum corneum was thinner. These observations enhance understanding of the wavelength-dependency and characteristics of light penetration of skin, which has potential for clinical impact regarding optimizing light-based diagnostic and therapeutic approaches for skin disease.
dc.relation.ispartofPhotochemistry and Photobiologyen
dc.subjectQC Physicsen
dc.titleDepth penetration of light into skin as a function of wavelength from 200 nm to 1000 nmen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. Office of the Principalen
dc.description.statusPeer revieweden

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