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Sphingolipid and ceramide homeostasis : potential therapeutic targets
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dc.contributor.author | Young, Simon | |
dc.contributor.author | Mina, John | |
dc.contributor.author | Denny, Paul | |
dc.contributor.author | Smith, Terry | |
dc.date.accessioned | 2012-03-08T16:01:04Z | |
dc.date.available | 2012-03-08T16:01:04Z | |
dc.date.issued | 2012 | |
dc.identifier | 13666061 | |
dc.identifier | 36e8afaf-5291-4c99-ba96-b7c3c7e8b3d4 | |
dc.identifier | 84858312051 | |
dc.identifier.citation | Young , S , Mina , J , Denny , P & Smith , T 2012 , ' Sphingolipid and ceramide homeostasis : potential therapeutic targets ' , Biochemistry Research International , vol. 2012 , 248135 . https://doi.org/10.1155/2012/248135 | en |
dc.identifier.issn | 2090-2247 | |
dc.identifier.other | ORCID: /0000-0003-1072-905X/work/38796294 | |
dc.identifier.uri | https://hdl.handle.net/10023/2412 | |
dc.description.abstract | Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has lead to a heightened interest in the possibility of targeting these processes for therapies against cancers, Alzheimer’s disease and numerous important human pathogens. In this review we outline the major pathways in eukaryotic sphingolipid metabolism and discuss these in relation to disease and therapy for both chronic and infectious conditions. | |
dc.format.extent | 12 | |
dc.format.extent | 725091 | |
dc.language.iso | eng | |
dc.relation.ispartof | Biochemistry Research International | en |
dc.subject | Sphingolipid | en |
dc.subject | Ceramide | en |
dc.subject | Health | en |
dc.subject | Disease | en |
dc.subject | Therapeutic target | en |
dc.subject | QH301 Biology | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QH301 | en |
dc.title | Sphingolipid and ceramide homeostasis : potential therapeutic targets | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | 10.1155/2012/248135 | |
dc.description.status | Peer reviewed | en |
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