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dc.contributor.authorYoung, Simon
dc.contributor.authorMina, John
dc.contributor.authorDenny, Paul
dc.contributor.authorSmith, Terry
dc.identifier.citationYoung , S , Mina , J , Denny , P & Smith , T 2012 , ' Sphingolipid and ceramide homeostasis : potential therapeutic targets ' Biochemistry Research International , vol. 2012 , 248135 .
dc.identifier.otherPURE: 13666061
dc.identifier.otherPURE UUID: 36e8afaf-5291-4c99-ba96-b7c3c7e8b3d4
dc.identifier.otherScopus: 84858312051
dc.identifier.otherORCID: /0000-0003-1072-905X/work/38796294
dc.description.abstractSphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has lead to a heightened interest in the possibility of targeting these processes for therapies against cancers, Alzheimer’s disease and numerous important human pathogens. In this review we outline the major pathways in eukaryotic sphingolipid metabolism and discuss these in relation to disease and therapy for both chronic and infectious conditions.
dc.relation.ispartofBiochemistry Research Internationalen
dc.rightsCopyright © 2012 Simon A. Young et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectTherapeutic targeten
dc.subjectQH301 Biologyen
dc.titleSphingolipid and ceramide homeostasis : potential therapeutic targetsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

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