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Sphingolipid and ceramide homeostasis : potential therapeutic targets

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YoungetalBiochemResInt2012Sphingolipid.pdf (708.0Kb)
Date
2012
Author
Young, Simon
Mina, John
Denny, Paul
Smith, Terry
Keywords
Sphingolipid
Ceramide
Health
Disease
Therapeutic target
QH301 Biology
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Abstract
Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has lead to a heightened interest in the possibility of targeting these processes for therapies against cancers, Alzheimer’s disease and numerous important human pathogens. In this review we outline the major pathways in eukaryotic sphingolipid metabolism and discuss these in relation to disease and therapy for both chronic and infectious conditions.
Citation
Young , S , Mina , J , Denny , P & Smith , T 2012 , ' Sphingolipid and ceramide homeostasis : potential therapeutic targets ' , Biochemistry Research International , vol. 2012 , 248135 . https://doi.org/10.1155/2012/248135
Publication
Biochemistry Research International
Status
Peer reviewed
DOI
https://doi.org/10.1155/2012/248135
ISSN
2090-2247
Type
Journal article
Rights
Copyright © 2012 Simon A. Young et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/2412

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