Sphingolipid and ceramide homeostasis : potential therapeutic targets
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Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has lead to a heightened interest in the possibility of targeting these processes for therapies against cancers, Alzheimer’s disease and numerous important human pathogens. In this review we outline the major pathways in eukaryotic sphingolipid metabolism and discuss these in relation to disease and therapy for both chronic and infectious conditions.
Young , S , Mina , J , Denny , P & Smith , T 2012 , ' Sphingolipid and ceramide homeostasis : potential therapeutic targets ' Biochemistry Research International , vol 2012 , 248135 . DOI: 10.1155/2012/248135
Biochemistry Research International
Copyright © 2012 Simon A. Young et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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