Synthesis of indoloquinolines : an intramolecular cyclization leading to advanced Perophoramidine-relevant intermediates
Abstract
The bioactive natural product perophoramidine has proved a challenging synthetic target. An alternative route to its indolo[2,3-b]quinolone core structure involving an N-chlorosuccinimde mediated intramolecular cylization reaction is reported. Attempts to progress towards the natural product are also discussed with an unexpected deep-seated rearrangement of the core structure occurring during an attempted iodoetherification reaction. X-ray crystallographic analysis provides important analytical confirmation of assigned structures.
Citation
Johnston , C A , Cordes , D B , Lebl , T , Slawin , A M Z & Westwood , N J 2021 , ' Synthesis of indoloquinolines : an intramolecular cyclization leading to advanced Perophoramidine-relevant intermediates ' , Molecules , vol. 26 , no. 19 , 6039 . https://doi.org/10.3390/molecules26196039
Publication
Molecules
Status
Peer reviewed
ISSN
1420-3049Type
Journal article
Description
We thank EPSRC (UK) for a DTA studentship for C.A.J.Collections
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