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dc.contributor.authorMcLean, Liam
dc.contributor.authorWatson, Allan J. B.
dc.date.accessioned2021-09-15T17:30:10Z
dc.date.available2021-09-15T17:30:10Z
dc.date.issued2021-09-15
dc.identifier.citationMcLean , L & Watson , A J B 2021 , ' An alternative synthesis of cycloalkyl-substituted CPA catalysts and application in asymmetric protonation reactions ' , European Journal of Organic Chemistry , no. 35 , pp. 4943-4945 . https://doi.org/10.1002/ejoc.202100980en
dc.identifier.issn1434-193X
dc.identifier.otherPURE: 275671304
dc.identifier.otherPURE UUID: f3b51a22-d331-472a-a2e9-3042fa6c3687
dc.identifier.otherORCID: /0000-0002-1582-4286/work/100172890
dc.identifier.urihttp://hdl.handle.net/10023/23964
dc.descriptionLAM thanks the EPSRC (grant number EP/S027165/1) for postdoctoral funding.en
dc.description.abstractAn alternative synthesis of cycloalkyl-substituted CPA catalysts is reported. A Negishi coupling offers improved yields and purity of the necessary 1,3,5-tri(cycloalkyl)benzenes. Limitations in the use of commercial organozinc reagents have been identified and a robust procedure for the preparation of these reagents is detailed. Similarly, a robust procedure for the key Kumada coupling is also provided. The route is demonstrated by preparation of three different tri(cycloalkyl)aryl-substituted CPAs and the utility of these catalysts in asymmetric protonation reactions is shown.
dc.format.extent4
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Organic Chemistryen
dc.rightsCopyright © 2021 The Authors. European Journal of Organic Chemistry published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectAsymmetric protonationen
dc.subjectBrønsted aciden
dc.subjectCatalysisen
dc.subjectCross-couplingen
dc.subjectEnantioselectivityen
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQDen
dc.titleAn alternative synthesis of cycloalkyl-substituted CPA catalysts and application in asymmetric protonation reactionsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.contributor.institutionUniversity of St Andrews.Sir James Mackenzie Institute for Early Diagnosisen
dc.identifier.doihttps://doi.org/10.1002/ejoc.202100980
dc.description.statusPeer revieweden


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