An alternative synthesis of cycloalkyl-substituted CPA catalysts and application in asymmetric protonation reactions
Abstract
An alternative synthesis of cycloalkyl-substituted CPA catalysts is reported. A Negishi coupling offers improved yields and purity of the necessary 1,3,5-tri(cycloalkyl)benzenes. Limitations in the use of commercial organozinc reagents have been identified and a robust procedure for the preparation of these reagents is detailed. Similarly, a robust procedure for the key Kumada coupling is also provided. The route is demonstrated by preparation of three different tri(cycloalkyl)aryl-substituted CPAs and the utility of these catalysts in asymmetric protonation reactions is shown.
Citation
McLean , L & Watson , A J B 2021 , ' An alternative synthesis of cycloalkyl-substituted CPA catalysts and application in asymmetric protonation reactions ' , European Journal of Organic Chemistry , no. 35 , pp. 4943-4945 . https://doi.org/10.1002/ejoc.202100980
Publication
European Journal of Organic Chemistry
Status
Peer reviewed
ISSN
1434-193XType
Journal article
Description
LAM thanks the EPSRC (grant number EP/S027165/1) for postdoctoral funding.Collections
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