An alternative synthesis of cycloalkyl-substituted CPA catalysts and application in asymmetric protonation reactions
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An alternative synthesis of cycloalkyl-substituted CPA catalysts is reported. A Negishi coupling offers improved yields and purity of the necessary 1,3,5-tri(cycloalkyl)benzenes. Limitations in the use of commercial organozinc reagents have been identified and a robust procedure for the preparation of these reagents is detailed. Similarly, a robust procedure for the key Kumada coupling is also provided. The route is demonstrated by preparation of three different tri(cycloalkyl)aryl-substituted CPAs and the utility of these catalysts in asymmetric protonation reactions is shown.
McLean , L & Watson , A J B 2021 , ' An alternative synthesis of cycloalkyl-substituted CPA catalysts and application in asymmetric protonation reactions ' , European Journal of Organic Chemistry , no. 35 , pp. 4943-4945 . https://doi.org/10.1002/ejoc.202100980
European Journal of Organic Chemistry
Copyright © 2021 The Authors. European Journal of Organic Chemistry published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
DescriptionLAM thanks the EPSRC (grant number EP/S027165/1) for postdoctoral funding.
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