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Questions in the chemical enzymology of MAO
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dc.contributor.author | Ramsay, Rona R. | |
dc.contributor.author | Albreht, Alen | |
dc.date.accessioned | 2021-09-02T08:30:07Z | |
dc.date.available | 2021-09-02T08:30:07Z | |
dc.date.issued | 2021-08-31 | |
dc.identifier.citation | Ramsay , R R & Albreht , A 2021 , ' Questions in the chemical enzymology of MAO ' , Chemistry , vol. 3 , no. 3 , pp. 959-978 . https://doi.org/10.3390/chemistry3030069 | en |
dc.identifier.issn | 2624-8549 | |
dc.identifier.other | PURE: 275669868 | |
dc.identifier.other | PURE UUID: 26b3534b-c8f5-4c9f-990e-1daafe39681d | |
dc.identifier.other | WOS: 000703015300001 | |
dc.identifier.other | Scopus: 85124125247 | |
dc.identifier.uri | http://hdl.handle.net/10023/23890 | |
dc.description | A.A. is supported by the Slovenian Research Agency (Research Program P1-0005). | en |
dc.description.abstract | We have structure, a wealth of kinetic data, thousands of chemical ligands, and clinical 8 information for the effects of a range of drugs on monoamine oxidase activity in vivo. We have 9 comparative information from various species and mutations on kinetics, and effects of inhibition. 10 Yet there are what seem like simple questions still to be answered. This article presents a brief sum-11 mary of existing experimental evidence the background and poses questions that remain intriguing 12 for chemists and biochemists researching the chemical enzymology of and drug design for mono-13 amine oxidases (FAD-containing EC 4.1.3.4). | |
dc.language.iso | eng | |
dc.relation.ispartof | Chemistry | en |
dc.rights | Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | en |
dc.subject | Chemical mechanism | en |
dc.subject | Kinetic mechanism | en |
dc.subject | Oxidation | en |
dc.subject | Protein flexibiity | en |
dc.subject | Cysteine modification | en |
dc.subject | Reversible/irreversible inhibition | en |
dc.subject | Molecular dynmaics | en |
dc.subject | Simulation | en |
dc.subject | QD Chemistry | en |
dc.subject.lcc | QD | en |
dc.title | Questions in the chemical enzymology of MAO | en |
dc.type | Journal item | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.identifier.doi | https://doi.org/10.3390/chemistry3030069 | |
dc.description.status | Peer reviewed | en |
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