Questions in the chemical enzymology of MAO

Abstract

We have structure, a wealth of kinetic data, thousands of chemical ligands, and clinical 8 information for the effects of a range of drugs on monoamine oxidase activity in vivo. We have 9 comparative information from various species and mutations on kinetics, and effects of inhibition. 10 Yet there are what seem like simple questions still to be answered. This article presents a brief sum-11 mary of existing experimental evidence the background and poses questions that remain intriguing 12 for chemists and biochemists researching the chemical enzymology of and drug design for mono-13 amine oxidases (FAD-containing EC 4.1.3.4).