Questions in the chemical enzymology of MAO
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We have structure, a wealth of kinetic data, thousands of chemical ligands, and clinical 8 information for the effects of a range of drugs on monoamine oxidase activity in vivo. We have 9 comparative information from various species and mutations on kinetics, and effects of inhibition. 10 Yet there are what seem like simple questions still to be answered. This article presents a brief sum-11 mary of existing experimental evidence the background and poses questions that remain intriguing 12 for chemists and biochemists researching the chemical enzymology of and drug design for mono-13 amine oxidases (FAD-containing EC 188.8.131.52).
Ramsay , R R & Albreht , A 2021 , ' Questions in the chemical enzymology of MAO ' , Chemistry , vol. 3 , no. 3 , pp. 959-978 . https://doi.org/10.3390/chemistry3030069
Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
DescriptionA.A. is supported by the Slovenian Research Agency (Research Program P1-0005).
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