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Accurate epigenetic aging in bottlenose dolphins (Tursiops truncatus), an essential step in the conservation of at-risk dolphins
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dc.contributor.author | Barratclough, Ashley | |
dc.contributor.author | Smith, Cynthia R. | |
dc.contributor.author | Gomez, Forrest M. | |
dc.contributor.author | Photopoulou, Theoni | |
dc.contributor.author | Takeshita, Ryan | |
dc.contributor.author | Pirotta, Enrico | |
dc.contributor.author | Thomas, Len | |
dc.contributor.author | McClain, Abby M. | |
dc.contributor.author | Parry, Celeste | |
dc.contributor.author | Zoller, Joseph A. | |
dc.contributor.author | Horvath, Steve | |
dc.contributor.author | Schwacke, Lori H. | |
dc.date.accessioned | 2021-08-06T09:30:03Z | |
dc.date.available | 2021-08-06T09:30:03Z | |
dc.date.issued | 2021-08-06 | |
dc.identifier | 275345747 | |
dc.identifier | a9483e6a-a153-44ed-95cb-c345d84fb1aa | |
dc.identifier | 85136865203 | |
dc.identifier.citation | Barratclough , A , Smith , C R , Gomez , F M , Photopoulou , T , Takeshita , R , Pirotta , E , Thomas , L , McClain , A M , Parry , C , Zoller , J A , Horvath , S & Schwacke , L H 2021 , ' Accurate epigenetic aging in bottlenose dolphins ( Tursiops truncatus ), an essential step in the conservation of at-risk dolphins ' , Journal of Zoological and Botanical Gardens , vol. 2 , no. 3 , pp. 416-420 . https://doi.org/10.3390/jzbg2030030 | en |
dc.identifier.issn | 2673-5636 | |
dc.identifier.other | Bibtex: jzbg2030030 | |
dc.identifier.other | ORCID: /0000-0002-7436-067X/work/98196617 | |
dc.identifier.other | ORCID: /0000-0001-9616-9940/work/98196866 | |
dc.identifier.other | ORCID: /0000-0003-3541-3676/work/106838540 | |
dc.identifier.uri | https://hdl.handle.net/10023/23728 | |
dc.description | Funding: This research was funded by SERDP grant RC20-C2-1097 awarded to Peter Tyack and Prescott Award NA20NMF4390132 awarded to Ashley Barratclough. | en |
dc.description.abstract | Epigenetics, specifically DNA methylation, allows for the estimation of animal age from blood or remotely sampled skin. This multi-tissue epigenetic age estimation clock uses 110 longitudinal samples from 34 Navy bottlenose dolphins (Tursiops truncatus), identifying 195 cytosine-phosphate-guanine sites associated with chronological aging via cross-validation with one individual left out in each fold (R2 = 0.95). With a median absolute error of 2.5 years, this clock improves age estimation capacity in wild dolphins, helping conservation efforts and enabling a better understanding of population demographics | |
dc.format.extent | 5 | |
dc.format.extent | 563187 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Zoological and Botanical Gardens | en |
dc.subject | DNA methylation | en |
dc.subject | Epigenetics | en |
dc.subject | Aging | en |
dc.subject | Bottlenose dolphin | en |
dc.subject | Chronological age | en |
dc.subject | QH301 Biology | en |
dc.subject | GE Environmental Sciences | en |
dc.subject | NDAS | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | GE | en |
dc.title | Accurate epigenetic aging in bottlenose dolphins (Tursiops truncatus), an essential step in the conservation of at-risk dolphins | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Mathematics and Statistics | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Statistics | en |
dc.contributor.institution | University of St Andrews. Centre for Research into Ecological & Environmental Modelling | en |
dc.contributor.institution | University of St Andrews. Marine Alliance for Science & Technology Scotland | en |
dc.identifier.doi | https://doi.org/10.3390/jzbg2030030 | |
dc.description.status | Peer reviewed | en |
dc.identifier.url | https://www.mdpi.com/2673-5636/2/3/30 | en |
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