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Accurate epigenetic aging in bottlenose dolphins (Tursiops truncatus), an essential step in the conservation of at-risk dolphins

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dc.contributor.authorBarratclough, Ashley
dc.contributor.authorSmith, Cynthia R.
dc.contributor.authorGomez, Forrest M.
dc.contributor.authorPhotopoulou, Theoni
dc.contributor.authorTakeshita, Ryan
dc.contributor.authorPirotta, Enrico
dc.contributor.authorThomas, Len
dc.contributor.authorMcClain, Abby M.
dc.contributor.authorParry, Celeste
dc.contributor.authorZoller, Joseph A.
dc.contributor.authorHorvath, Steve
dc.contributor.authorSchwacke, Lori H.
dc.date.accessioned2021-08-06T09:30:03Z
dc.date.available2021-08-06T09:30:03Z
dc.date.issued2021-08-06
dc.identifier275345747
dc.identifiera9483e6a-a153-44ed-95cb-c345d84fb1aa
dc.identifier85136865203
dc.identifier.citationBarratclough , A , Smith , C R , Gomez , F M , Photopoulou , T , Takeshita , R , Pirotta , E , Thomas , L , McClain , A M , Parry , C , Zoller , J A , Horvath , S & Schwacke , L H 2021 , ' Accurate epigenetic aging in bottlenose dolphins ( Tursiops truncatus ), an essential step in the conservation of at-risk dolphins ' , Journal of Zoological and Botanical Gardens , vol. 2 , no. 3 , pp. 416-420 . https://doi.org/10.3390/jzbg2030030en
dc.identifier.issn2673-5636
dc.identifier.otherBibtex: jzbg2030030
dc.identifier.otherORCID: /0000-0002-7436-067X/work/98196617
dc.identifier.otherORCID: /0000-0001-9616-9940/work/98196866
dc.identifier.otherORCID: /0000-0003-3541-3676/work/106838540
dc.identifier.urihttps://hdl.handle.net/10023/23728
dc.descriptionFunding: This research was funded by SERDP grant RC20-C2-1097 awarded to Peter Tyack and Prescott Award NA20NMF4390132 awarded to Ashley Barratclough.en
dc.description.abstractEpigenetics, specifically DNA methylation, allows for the estimation of animal age from blood or remotely sampled skin. This multi-tissue epigenetic age estimation clock uses 110 longitudinal samples from 34 Navy bottlenose dolphins (Tursiops truncatus), identifying 195 cytosine-phosphate-guanine sites associated with chronological aging via cross-validation with one individual left out in each fold (R2 = 0.95). With a median absolute error of 2.5 years, this clock improves age estimation capacity in wild dolphins, helping conservation efforts and enabling a better understanding of population demographics
dc.format.extent5
dc.format.extent563187
dc.language.isoeng
dc.relation.ispartofJournal of Zoological and Botanical Gardensen
dc.subjectDNA methylationen
dc.subjectEpigeneticsen
dc.subjectAgingen
dc.subjectBottlenose dolphinen
dc.subjectChronological ageen
dc.subjectQH301 Biologyen
dc.subjectGE Environmental Sciencesen
dc.subjectNDASen
dc.subject.lccQH301en
dc.subject.lccGEen
dc.titleAccurate epigenetic aging in bottlenose dolphins (Tursiops truncatus), an essential step in the conservation of at-risk dolphinsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Mathematics and Statisticsen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Statisticsen
dc.contributor.institutionUniversity of St Andrews. Centre for Research into Ecological & Environmental Modellingen
dc.contributor.institutionUniversity of St Andrews. Marine Alliance for Science & Technology Scotlanden
dc.identifier.doi10.3390/jzbg2030030
dc.description.statusPeer revieweden
dc.identifier.urlhttps://www.mdpi.com/2673-5636/2/3/30en


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