Accurate epigenetic aging in bottlenose dolphins (Tursiops truncatus), an essential step in the conservation of at-risk dolphins
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Epigenetics, specifically DNA methylation, allows for the estimation of animal age from blood or remotely sampled skin. This multi-tissue epigenetic age estimation clock uses 110 longitudinal samples from 34 Navy bottlenose dolphins (Tursiops truncatus), identifying 195 cytosine-phosphate-guanine sites associated with chronological aging via cross-validation with one individual left out in each fold (R2 = 0.95). With a median absolute error of 2.5 years, this clock improves age estimation capacity in wild dolphins, helping conservation efforts and enabling a better understanding of population demographics
Barratclough , A , Smith , C R , Gomez , F M , Photopoulou , T , Takeshita , R , Pirotta , E , Thomas , L , McClain , A M , Parry , C , Zoller , J A , Horvath , S & Schwacke , L H 2021 , ' Accurate epigenetic aging in bottlenose dolphins ( Tursiops truncatus ), an essential step in the conservation of at-risk dolphins ' , Journal of Zoological and Botanical Gardens , vol. 2 , no. 3 , pp. 416-420 . https://doi.org/10.3390/jzbg2030030
Journal of Zoological and Botanical Gardens
Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/4.0/).
DescriptionFunding: This research was funded by SERDP grant RC20-C2-1097 awarded to Peter Tyack and Prescott Award NA20NMF4390132 awarded to Ashley Barratclough.
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