Structure of chimpanzee gut microbiomes across tropical Africa
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Understanding variation in host-associated microbial communities is important given the relevance of microbiomes to host physiology and health. Using 560 fecal samples collected from wild chimpanzees (Pan troglodytes) across their range, we assessed how geography, genetics, climate, vegetation, and diet relate to gut microbial community structure (prokaryotes, eukaryotic parasites) at multiple spatial scales. We observed a high degree of regional specificity in the microbiome composition, which was associated with host genetics, available plant foods, and potentially with cultural differences in tool use, which affect diet. Genetic differences drove community composition at large scales, while vegetation and potentially tool use drove within-region differences, likely due to their influence on diet. Unlike industrialized human populations in the United States, where regional differences in the gut microbiome are undetectable, chimpanzee gut microbiomes are far more variable across space, suggesting that technological developments have decoupled humans from their local environments, obscuring regional differences that could have been important during human evolution.
Bueno De Mesquita , C P , Nichols , L M , Gebert , M J , Vanderburgh , C , Bocksberger , G , Lester , J D , Kalan , A K , Dieguez , P , Mccarthy , M S , Agbor , A , Álvarez Varona , P , Ayimisin , A E , Bessone , M , Chancellor , R , Cohen , H , Coupland , C , Deschner , T , Egbe , V E , Goedmakers , A , Granjon , A-C , Grueter , C C , Head , J , Hernandez-Aguilar , R A , Jeffery , K J , Jones , S , Kadam , P , Kaiser , M , Lapuente , J , Larson , B , Marrocoli , S , Morgan , D , Mugerwa , B , Mulindahabi , F , Neil , E , Niyigaba , P , Pacheco , L , Piel , A K , Robbins , M M , Rundus , A , Sanz , C M , Sciaky , L , Sheil , D , Sommer , V , Stewart , F A , Ton , E , Van Schijndel , J , Vergnes , V , Wessling , E G , Wittig , R M , Ginath Yuh , Y , Yurkiw , K , Zuberbühler , K , Gogarten , J F , Heintz-Buschart , A , Muellner-Riehl , A N , Boesch , C , Kühl , H S , Fierer , N , Arandjelovic , M & Dunn , R R 2021 , ' Structure of chimpanzee gut microbiomes across tropical Africa ' , mSystems , vol. 6 , no. 3 , e01269-20 . https://doi.org/10.1128/mSystems.01269-20
Copyright © 2021 Bueno de Mesquita et al. This is an open-access article distributed under the terms of the Creative Commons https://creativecommons.org/licenses/by/4.0/
DescriptionWe acknowledge the Max Planck Society, the Max Planck Society Innovation Fund, and the Heinz L. Krekeler Foundation for funding. J.F.G. was supported by the Deutsche Forschungsgemeinschaft (DFG) Research Group “Sociality and Health in Primates” (FOR2136). Publication of this article was funded by the University of Colorado Boulder Libraries Open Access Fund.
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