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Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision making

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Date
11/2006
Author
Schweimer, Judith
Hauber, Wolfgang
Keywords
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Cellular and Molecular Neuroscience
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Abstract
The anterior cingulate cortex (ACC) has been implicated in encoding whether or not an action is worth performing in view of the expected benefit and the cost of performing the action. Dopamine input to the ACC may be critical for this form of effort-based decision making; however, the role of distinct ACC dopamine receptors is yet unknown. Therefore, we examined in rats the effects of an intra-ACC D1 and D2 receptor blockade on effort-based decision making tested in a T-maze cost-benefit task. In this task, subjects could either choose to climb a barrier to obtain a high reward in one arm or a low reward in the other arm without a barrier. Unlike vehicle-treated rats, rats with intra-ACC infusion of the D1 receptor antagonist SCH23390 exhibited a reduced preference for the high-cost-high-reward response option when having the choice to obtain a low reward with little effort. In contrast, in rats with intra-ACC infusion of the D2 receptor antagonist eticlopride, the preference for the high-cost-high-reward response option was not altered relative to vehicle-treated rats. These data provide the first evidence that D1 receptors in the ACC regulate effort-based decision making.
Citation
Schweimer , J & Hauber , W 2006 , ' Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision making ' , Learning and Memory , vol. 13 , no. 6 , pp. 777-782 . https://doi.org/10.1101/lm.409306
Publication
Learning and Memory
Status
Peer reviewed
DOI
https://doi.org/10.1101/lm.409306
ISSN
1072-0502
Type
Journal article
Rights
Copyright © 2006, Cold Spring Harbor Laboratory Press. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the final published version of the work, which was originally published at https://doi.org/10.1101/lm.409306
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/23594

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