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dc.contributor.authorHeckman, P R A
dc.contributor.authorSchweimer, Judith
dc.contributor.authorSharp, T
dc.contributor.authorPrickaerts, T
dc.contributor.authorBlockland, A
dc.date.accessioned2021-07-16T09:30:02Z
dc.date.available2021-07-16T09:30:02Z
dc.date.issued2018-03
dc.identifier.citationHeckman , P R A , Schweimer , J , Sharp , T , Prickaerts , T & Blockland , A 2018 , ' Phosphodiesterase 4 Inhibition affects both the direct and indirect pathway : an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata ' , Brain Structure and Function , vol. 223 , pp. 739-748 . https://doi.org/10.1007/s00429-017-1518-8en
dc.identifier.issn1863-2653
dc.identifier.otherPURE: 275052615
dc.identifier.otherPURE UUID: 632661d4-3e41-4007-ab0e-c8e6618fe24c
dc.identifier.otherScopus: 85029604269
dc.identifier.otherORCID: /0000-0002-5968-3534/work/108119026
dc.identifier.urihttps://hdl.handle.net/10023/23585
dc.description.abstractFronto-striatal circuits constitute the neurobiological basis of many neuropsychiatric disorders. Part of the intracellular signaling within these circuits, including its dopaminergic modulation, is regulated by the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling cascade. Based on the overall expression in human fronto-striatal circuitry, we tested the effects of a cAMP selective phosphodiesterase 4 (PDE4) inhibitor on the tri-phasic response in the dorsomedial substantia nigra pars reticulata (SNr) upon stimulation of the infralimbic cortex in rats. Our results show for the first time that stimulation of the cognitive infralimbic cortex leads to a tri-phasic response in SNr neurons. In addition and in line with previous biochemical and behavioral studies, PDE4 inhibition by roflumilast affects the direct pathway as well as the indirect pathway of which the latter appears more sensitive than the former.
dc.language.isoeng
dc.relation.ispartofBrain Structure and Functionen
dc.rightsCopyright © The Author(s) 2017. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en
dc.subjectPhosphodiesterase inhibitoren
dc.subjectRoflumilasten
dc.subjectSubstantia nigra pars reticulataen
dc.subjectFronto-striatal circuitsen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectNDASen
dc.subject.lccRC0321en
dc.titlePhosphodiesterase 4 Inhibition affects both the direct and indirect pathway : an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulataen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.identifier.doihttps://doi.org/10.1007/s00429-017-1518-8
dc.description.statusPeer revieweden


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