Phosphodiesterase 4 Inhibition affects both the direct and indirect pathway : an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata
Abstract
Fronto-striatal circuits constitute the neurobiological basis of many neuropsychiatric disorders. Part of the intracellular signaling within these circuits, including its dopaminergic modulation, is regulated by the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling cascade. Based on the overall expression in human fronto-striatal circuitry, we tested the effects of a cAMP selective phosphodiesterase 4 (PDE4) inhibitor on the tri-phasic response in the dorsomedial substantia nigra pars reticulata (SNr) upon stimulation of the infralimbic cortex in rats. Our results show for the first time that stimulation of the cognitive infralimbic cortex leads to a tri-phasic response in SNr neurons. In addition and in line with previous biochemical and behavioral studies, PDE4 inhibition by roflumilast affects the direct pathway as well as the indirect pathway of which the latter appears more sensitive than the former.
Citation
Heckman , P R A , Schweimer , J , Sharp , T , Prickaerts , T & Blockland , A 2018 , ' Phosphodiesterase 4 Inhibition affects both the direct and indirect pathway : an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata ' , Brain Structure and Function , vol. 223 , pp. 739-748 . https://doi.org/10.1007/s00429-017-1518-8
Publication
Brain Structure and Function
Status
Peer reviewed
ISSN
1863-2653Type
Journal article
Rights
Copyright © The Author(s) 2017. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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