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dc.contributor.authorHiramoto, Atsuki
dc.contributor.authorJonaitis, Julius
dc.contributor.authorNiki, Sawako
dc.contributor.authorKohsaka, Hiroshi
dc.contributor.authorFetter, Richard D.
dc.contributor.authorCardona, Albert
dc.contributor.authorPulver, Stefan R.
dc.contributor.authorNose, Akinao
dc.identifier.citationHiramoto , A , Jonaitis , J , Niki , S , Kohsaka , H , Fetter , R D , Cardona , A , Pulver , S R & Nose , A 2021 , ' Regulation of coordinated muscular relaxation in Drosophila larvae by a pattern-regulating intersegmental circuit ' , Nature Communications , vol. 12 , 2943 .
dc.identifier.otherORCID: /0000-0001-5170-7522/work/94669849
dc.descriptionThis work was supported by HHMI Janelia Visitor program (A.H. and S.R.P. hosted by A.C.), the Howard Hughes Medical Institute (R.D.F. and A.C.), Wellcome Trust Institutional Strategic Support Funds (105621/Z/14/Z) (S.R.P.), a Royal Society Research Grant (RG150108) (S.R.P.), and MEXT/JSPS KAKENHI grants (20K06908 and 17K07042 to H.K., 15H04255, 17H05554, 18H05113, 19H04742, and 20H05048 to A.N.).en
dc.description.abstractTypical patterned movements in animals are achieved through combinations of contraction and delayed relaxation of groups of muscles. However, how intersegmentally coordinated patterns of muscular relaxation are regulated by the neural circuits remains poorly understood. Here, we identify Canon, a class of higher-order premotor interneurons, that regulates muscular relaxation during backward locomotion of Drosophila larvae. Canon neurons are cholinergic interneurons present in each abdominal neuromere and show wave-like activity during fictive backward locomotion. Optogenetic activation of Canon neurons induces relaxation of body wall muscles, whereas inhibition of these neurons disrupts timely muscle relaxation. Canon neurons provide excitatory outputs to inhibitory premotor interneurons. Canon neurons also connect with each other to form an intersegmental circuit and regulate their own wave-like activities. Thus, our results demonstrate how coordinated muscle relaxation can be realized by an intersegmental circuit that regulates its own patterned activity and sequentially terminates motor activities along the anterior-posterior axis.
dc.relation.ispartofNature Communicationsen
dc.subjectCentral pattern generatorsen
dc.subjectMotor neuronen
dc.subjectQP Physiologyen
dc.titleRegulation of coordinated muscular relaxation in Drosophila larvae by a pattern-regulating intersegmental circuiten
dc.typeJournal articleen
dc.contributor.sponsorThe Wellcome Trusten
dc.contributor.sponsorThe Royal Societyen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.description.statusPeer revieweden

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