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A nearly-neutral biallelic Moran model with biased mutation and linear and quadratic selection
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dc.contributor.author | Vogl, Claus | |
dc.contributor.author | Mikula, Lynette Caitlin | |
dc.date.accessioned | 2021-05-24T14:30:12Z | |
dc.date.available | 2021-05-24T14:30:12Z | |
dc.date.issued | 2021-06 | |
dc.identifier | 274343599 | |
dc.identifier | 002e1d90-ef34-4374-ab46-d1685537a268 | |
dc.identifier | 33964284 | |
dc.identifier | 85105581278 | |
dc.identifier | 000656535400001 | |
dc.identifier.citation | Vogl , C & Mikula , L C 2021 , ' A nearly-neutral biallelic Moran model with biased mutation and linear and quadratic selection ' , Theoretical Population Biology , vol. 139 , pp. 1-17 . https://doi.org/10.1016/j.tpb.2021.03.003 | en |
dc.identifier.issn | 0040-5809 | |
dc.identifier.other | Jisc: 9c44410671494690b414f20be1163ea5 | |
dc.identifier.other | pii: S0040-5809(21)00028-9 | |
dc.identifier.other | ORCID: /0000-0002-0252-4014/work/94669890 | |
dc.identifier.uri | https://hdl.handle.net/10023/23238 | |
dc.description | CV’s research is supported by the Austrian Science Fund (FWF): DK W1225-B20; LCM’s by the School of Biology at the University of St.Andrews and has been partially funded through Vienna Science and Technology Fund (WWTF), Austria [MA016-061]. | en |
dc.description.abstract | In this article, a biallelic reversible mutation model with linear and quadratic selection is analysed. The approach reconnects to one proposed by Kimura (1979), who starts from a diffusion model and derives its equilibrium distribution up to a constant. We use a boundary-mutation Moran model, which approximates a general mutation model for small effective mutation rates, and derive its equilibrium distribution for polymorphic and monomorphic variants in small to moderately sized populations. Using this model, we show that biased mutation rates and linear selection alone can cause patterns of polymorphism within and substitution rates between populations that are usually ascribed to balancing or overdominant selection. We illustrate this using a data set of short introns and fourfold degenerate sites from Drosophila simulans and Drosophila melanogaster. | |
dc.format.extent | 1618455 | |
dc.language.iso | eng | |
dc.relation.ispartof | Theoretical Population Biology | en |
dc.subject | Linear and quadratic selection | en |
dc.subject | McDonald–Kreitman test | en |
dc.subject | Moran model | en |
dc.subject | Mutation bias | en |
dc.subject | Mutation–selection–drift equilibrium | en |
dc.subject | Nearly-neutral theory | en |
dc.subject | QA Mathematics | en |
dc.subject | QH301 Biology | en |
dc.subject | QH426 Genetics | en |
dc.subject | 3rd-DAS | en |
dc.subject | NIS | en |
dc.subject.lcc | QA | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | QH426 | en |
dc.title | A nearly-neutral biallelic Moran model with biased mutation and linear and quadratic selection | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. Centre for Biological Diversity | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.identifier.doi | 10.1016/j.tpb.2021.03.003 | |
dc.description.status | Peer reviewed | en |
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