A nearly-neutral biallelic Moran model with biased mutation and linear and quadratic selection
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In this article, a biallelic reversible mutation model with linear and quadratic selection is analysed. The approach reconnects to one proposed by Kimura (1979), who starts from a diffusion model and derives its equilibrium distribution up to a constant. We use a boundary-mutation Moran model, which approximates a general mutation model for small effective mutation rates, and derive its equilibrium distribution for polymorphic and monomorphic variants in small to moderately sized populations. Using this model, we show that biased mutation rates and linear selection alone can cause patterns of polymorphism within and substitution rates between populations that are usually ascribed to balancing or overdominant selection. We illustrate this using a data set of short introns and fourfold degenerate sites from Drosophila simulans and Drosophila melanogaster.
Vogl , C & Mikula , L C 2021 , ' A nearly-neutral biallelic Moran model with biased mutation and linear and quadratic selection ' , Theoretical Population Biology , vol. 139 , pp. 1-17 . https://doi.org/10.1016/j.tpb.2021.03.003
Theoretical Population Biology
Copyright © 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
DescriptionCV’s research is supported by the Austrian Science Fund (FWF): DK W1225-B20; LCM’s by the School of Biology at the University of St.Andrews and has been partially funded through Vienna Science and Technology Fund (WWTF), Austria [MA016-061].
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