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dc.contributor.authorFang, Qi
dc.contributor.authorFrewer, Luke
dc.contributor.authorZilkens, Renate
dc.contributor.authorKrajancich, Brooke
dc.contributor.authorCuratolo, Andrea
dc.contributor.authorChin, Lixin
dc.contributor.authorFoo, Ken Y
dc.contributor.authorLakhiani, Devina D
dc.contributor.authorSanderson, Rowan W
dc.contributor.authorWijesinghe, Philip
dc.contributor.authorAnstie, James D
dc.contributor.authorDessauvagie, Benjamin F
dc.contributor.authorLatham, Bruce
dc.contributor.authorSaunders, Christobel M
dc.contributor.authorKennedy, Brendan F
dc.identifier.citationFang , Q , Frewer , L , Zilkens , R , Krajancich , B , Curatolo , A , Chin , L , Foo , K Y , Lakhiani , D D , Sanderson , R W , Wijesinghe , P , Anstie , J D , Dessauvagie , B F , Latham , B , Saunders , C M & Kennedy , B F 2020 , ' Handheld volumetric manual compression-based quantitative microelastography ' , Journal of Biophotonics , vol. Early View , e201960196 .
dc.identifier.otherPURE: 266563249
dc.identifier.otherPURE UUID: 707981ed-baab-4501-bd16-2ee8590ec780
dc.identifier.otherPubMed: 32057188
dc.identifier.otherORCID: /0000-0002-8378-7261/work/70234064
dc.identifier.otherScopus: 85080104637
dc.identifier.otherWOS: 000516710400001
dc.descriptionThis research was supported by grants and fellowships from the Australian Research Council, the National Health and Medical Research Council (Australia), the National Breast Cancer Foundation (Australia), the Department of Health, Western Australia, the Cancer Council, Western Australia and through a research contract with OncoRes Medical, Australia.en
dc.description.abstractCompression optical coherence elastography (OCE) typically requires a mechanical actuator to impart a controlled uniform strain to the sample. However, for handheld scanning, this adds complexity to the design of the probe and the actuator stroke limits the amount of strain that can be applied. In this work, we present a new volumetric imaging approach that utilizes bidirectional manual compression via the natural motion of the user's hand to induce strain to the sample, realizing compact, actuator‐free, handheld compression OCE. In this way, we are able to demonstrate rapid acquisition of three‐dimensional quantitative microelastography (QME) datasets of a tissue volume (6 × 6 × 1 mm3) in 3.4 seconds. We characterize the elasticity sensitivity of this freehand manual compression approach using a homogeneous silicone phantom and demonstrate comparable performance to a benchtop mounted, actuator‐based approach. In addition, we demonstrate handheld volumetric manual compression‐based QME on a tissue‐mimicking phantom with an embedded stiff inclusion and on freshly excised human breast specimens from both mastectomy and wide local excision (WLE) surgeries. Tissue results are coregistered with postoperative histology, verifying the capability of our approach to measure the elasticity of tissue and to distinguish stiff tumor from surrounding soft benign tissue.
dc.relation.ispartofJournal of Biophotonicsen
dc.rightsCopyright © 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at
dc.subjectFreehand volumetric imagingen
dc.subjectHandheld probeen
dc.subjectOptical coherence elastographyen
dc.subjectOptical coherence tomographyen
dc.subjectQuantitative micro-elastrogrophyen
dc.subjectQC Physicsen
dc.subjectQH301 Biologyen
dc.subjectRD Surgeryen
dc.subjectT Technologyen
dc.titleHandheld volumetric manual compression-based quantitative microelastographyen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.description.statusPeer revieweden

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