Handheld volumetric manual compression-based quantitative microelastography
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Compression optical coherence elastography (OCE) typically requires a mechanical actuator to impart a controlled uniform strain to the sample. However, for handheld scanning, this adds complexity to the design of the probe and the actuator stroke limits the amount of strain that can be applied. In this work, we present a new volumetric imaging approach that utilizes bidirectional manual compression via the natural motion of the user's hand to induce strain to the sample, realizing compact, actuator‐free, handheld compression OCE. In this way, we are able to demonstrate rapid acquisition of three‐dimensional quantitative microelastography (QME) datasets of a tissue volume (6 × 6 × 1 mm3) in 3.4 seconds. We characterize the elasticity sensitivity of this freehand manual compression approach using a homogeneous silicone phantom and demonstrate comparable performance to a benchtop mounted, actuator‐based approach. In addition, we demonstrate handheld volumetric manual compression‐based QME on a tissue‐mimicking phantom with an embedded stiff inclusion and on freshly excised human breast specimens from both mastectomy and wide local excision (WLE) surgeries. Tissue results are coregistered with postoperative histology, verifying the capability of our approach to measure the elasticity of tissue and to distinguish stiff tumor from surrounding soft benign tissue.
Fang , Q , Frewer , L , Zilkens , R , Krajancich , B , Curatolo , A , Chin , L , Foo , K Y , Lakhiani , D D , Sanderson , R W , Wijesinghe , P , Anstie , J D , Dessauvagie , B F , Latham , B , Saunders , C M & Kennedy , B F 2020 , ' Handheld volumetric manual compression-based quantitative microelastography ' , Journal of Biophotonics , vol. Early View , e201960196 . https://doi.org/10.1002/jbio.201960196
Journal of Biophotonics
Copyright © 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1002/jbio.201960196
DescriptionThis research was supported by grants and fellowships from the Australian Research Council, the National Health and Medical Research Council (Australia), the National Breast Cancer Foundation (Australia), the Department of Health, Western Australia, the Cancer Council, Western Australia and through a research contract with OncoRes Medical, Australia.
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