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Antiviral drug discovery : preparing for the next pandemic

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dc.contributor.authorAdamson, Catherine S
dc.contributor.authorChibale, Kelly
dc.contributor.authorGoss, Rebecca
dc.contributor.authorJaspars, Marcel
dc.contributor.authorNewman, David J.
dc.contributor.authorDorrington, Rosemary A.
dc.date.accessioned2021-02-02T14:30:08Z
dc.date.available2021-02-02T14:30:08Z
dc.date.issued2021-02-01
dc.identifier271789344
dc.identifier1f1f7490-5894-46a7-aa1b-b2e833ed555f
dc.identifier85102078050
dc.identifier000635214300002
dc.identifier.citationAdamson , C S , Chibale , K , Goss , R , Jaspars , M , Newman , D J & Dorrington , R A 2021 , ' Antiviral drug discovery : preparing for the next pandemic ' , Chemical Society Reviews , vol. Advance Article . https://doi.org/10.1039/D0CS01118Een
dc.identifier.issn0306-0012
dc.identifier.urihttps://hdl.handle.net/10023/21355
dc.descriptionFunding: South African Medical Research Council (MRC) with funds received from the South African National Department of Health and the UK Government’s Newton Fund (R.A.D., RL.M.G., K.C.), the UK Engineering and Physical Sciences Research Council EQATA (R.J.M.G.), the UK Global Challenge Research Fund (R.J.M.G., R.A.D.), the University of Cape Town (K.C.) and the South African Research Chairs Initiative of the Department of Science and Innovation, administered through the South African National Research Foundation (K.C. R.A.D.). C.S.A. acknowledges financial support for SARS-CoV-2/Covid-19 research from UKMRC (CVG-1725-2020) and UKRI-DHSC (MR/V028464/1).en
dc.description.abstractClinically approved antiviral drugs are currently available for only 10 of the more than 220 viruses known to infect humans. The SARS-CoV-2 outbreak has exposed the critical need for compounds that can be rapidly mobilised for the treatment of re-emerging or emerging viral diseases, while vaccine development is underway. We review the current status of antiviral therapies focusing on RNA viruses, highlighting strategies for antiviral drug discovery and discuss the challenges, solutions and options to accelerate drug discovery efforts.
dc.format.extent9
dc.format.extent2362968
dc.language.isoeng
dc.relation.ispartofChemical Society Reviewsen
dc.subjectQD Chemistryen
dc.subjectQR355 Virologyen
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQDen
dc.subject.lccQR355en
dc.subject.lccRA0421en
dc.titleAntiviral drug discovery : preparing for the next pandemicen
dc.typeJournal itemen
dc.contributor.sponsorMedical Research Councilen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.identifier.doi10.1039/D0CS01118E
dc.description.statusPeer revieweden
dc.identifier.grantnumberMR/V028464/1en


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