Antiviral drug discovery : preparing for the next pandemic
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Clinically approved antiviral drugs are currently available for only 10 of the more than 220 viruses known to infect humans. The SARS-CoV-2 outbreak has exposed the critical need for compounds that can be rapidly mobilised for the treatment of re-emerging or emerging viral diseases, while vaccine development is underway. We review the current status of antiviral therapies focusing on RNA viruses, highlighting strategies for antiviral drug discovery and discuss the challenges, solutions and options to accelerate drug discovery efforts.
Adamson , C S , Chibale , K , Goss , R , Jaspars , M , Newman , D J & Dorrington , R A 2021 , ' Antiviral drug discovery : preparing for the next pandemic ' , Chemical Society Reviews , vol. Advance Article . https://doi.org/10.1039/D0CS01118E
Chemical Society Reviews
Copyright © 2021 the Author(s). Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
DescriptionFunding: South African Medical Research Council (MRC) with funds received from the South African National Department of Health and the UK Government’s Newton Fund (R.A.D., RL.M.G., K.C.), the UK Engineering and Physical Sciences Research Council EQATA (R.J.M.G.), the UK Global Challenge Research Fund (R.J.M.G., R.A.D.), the University of Cape Town (K.C.) and the South African Research Chairs Initiative of the Department of Science and Innovation, administered through the South African National Research Foundation (K.C. R.A.D.). C.S.A. acknowledges financial support for SARS-CoV-2/Covid-19 research from UKMRC (CVG-1725-2020) and UKRI-DHSC (MR/V028464/1).
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