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dc.contributor.authorBarac, Aleksandra
dc.contributor.authorCevik, Muge
dc.contributor.authorColovic, Natasa
dc.contributor.authorLekovic, Danijela
dc.contributor.authorStevanovic, Goran
dc.contributor.authorMicic, Jelena
dc.contributor.authorRubino, Salvatore
dc.date.accessioned2021-01-28T00:37:25Z
dc.date.available2021-01-28T00:37:25Z
dc.date.issued2020-01-28
dc.identifier265879649
dc.identifier16da1b00-6e8b-44bc-9fa9-8848072b95d6
dc.identifier31930592
dc.identifier85078658518
dc.identifier000509704100001
dc.identifier.citationBarac , A , Cevik , M , Colovic , N , Lekovic , D , Stevanovic , G , Micic , J & Rubino , S 2020 , ' Investigation of a healthcare associated Candida tropicalis candidiasis cluster in a haematology unit and a systematic review of nosocomial outbreaks ' , Mycoses , vol. Early View . https://doi.org/10.1111/myc.13048en
dc.identifier.issn0933-7407
dc.identifier.urihttps://hdl.handle.net/10023/21336
dc.descriptionDr Aleksandra Barac received support for research from the Project of Ministry of Education, Science and Technology of the Republic of Serbia (No. III45005).en
dc.description.abstractBackground Non‐albicans Candida spp. are an emerging cause of hospital‐bloodstream infections, associated with high mortality due to the challenges in diagnosis and delayed treatment. Objectives We aimed to investigate a cluster of healthcare associated invasive candidiasis caused by C. tropicalis and review the literature of healthcare associated outbreaks or clusters caused by C. tropicalis. Methods An investigation was performed to determine clinical presentation, treatment outcomes and the factors contributing to C. tropicalis candidemia occurrence. We searched the Medline database via PubMed and Ovid using the keywords of “Candida tropicalis” combined with “outbreak” or “clustering” or “clusters”, and we limited the search to studies conducted from January 1989 to January 2019 Results We report two related cases of C. tropicalis candidemia among patients with AML following a period of neutropenia, who had erythematous skin rash as a first manifesting sign of candidiasis. C. tropicalis was isolated from blood and skin cultures of both patients, which were identical by pulsed‐field gel electrophoresis typing. Our systematic review of outbreaks caused by C. tropicalis suggests that (1) most reported outbreaks have occurred in neonatal and adult ICUs, (2) patients who receive total parenteral therapy, antibiotics and those who have indwelling catheters and recent surgery are at high risk of infection, (3) environmental and healthcare personnel surveillance suggest that cross‐contamination is a major risk factor. Conclusion Control of nosocomial outbreaks caused by C. tropicalis should include better infection control measures, education of healthcare professionals especially working in adult and neonatal intensive care and haematology units.
dc.format.extent8407919
dc.language.isoeng
dc.relation.ispartofMycosesen
dc.subjectCandida tropicalisen
dc.subjectCandidemiaen
dc.subjectCandidiasisen
dc.subjectClusteren
dc.subjectCross-contaminationen
dc.subjectOutbreaken
dc.subjectRZ Other systems of medicineen
dc.subject.lccRZen
dc.titleInvestigation of a healthcare associated Candida tropicalis candidiasis cluster in a haematology unit and a systematic review of nosocomial outbreaksen
dc.typeJournal itemen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doi10.1111/myc.13048
dc.description.statusPeer revieweden
dc.date.embargoedUntil2021-01-28


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