St Andrews Research Repository

St Andrews University Home
View Item 
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Investigation of a healthcare associated Candida tropicalis candidiasis cluster in a haematology unit and a systematic review of nosocomial outbreaks

Thumbnail
View/Open
Barac_2020_Mycoses_Healthcare_AAM.pdf (8.018Mb)
Date
28/01/2020
Author
Barac, Aleksandra
Cevik, Muge
Colovic, Natasa
Lekovic, Danijela
Stevanovic, Goran
Micic, Jelena
Rubino, Salvatore
Keywords
Candida tropicalis
Candidemia
Candidiasis
Cluster
Cross-contamination
Outbreak
RZ Other systems of medicine
Metadata
Show full item record
Altmetrics Handle Statistics
Altmetrics DOI Statistics
Abstract
Background Non‐albicans Candida spp. are an emerging cause of hospital‐bloodstream infections, associated with high mortality due to the challenges in diagnosis and delayed treatment. Objectives We aimed to investigate a cluster of healthcare associated invasive candidiasis caused by C. tropicalis and review the literature of healthcare associated outbreaks or clusters caused by C. tropicalis. Methods An investigation was performed to determine clinical presentation, treatment outcomes and the factors contributing to C. tropicalis candidemia occurrence. We searched the Medline database via PubMed and Ovid using the keywords of “Candida tropicalis” combined with “outbreak” or “clustering” or “clusters”, and we limited the search to studies conducted from January 1989 to January 2019 Results We report two related cases of C. tropicalis candidemia among patients with AML following a period of neutropenia, who had erythematous skin rash as a first manifesting sign of candidiasis. C. tropicalis was isolated from blood and skin cultures of both patients, which were identical by pulsed‐field gel electrophoresis typing. Our systematic review of outbreaks caused by C. tropicalis suggests that (1) most reported outbreaks have occurred in neonatal and adult ICUs, (2) patients who receive total parenteral therapy, antibiotics and those who have indwelling catheters and recent surgery are at high risk of infection, (3) environmental and healthcare personnel surveillance suggest that cross‐contamination is a major risk factor. Conclusion Control of nosocomial outbreaks caused by C. tropicalis should include better infection control measures, education of healthcare professionals especially working in adult and neonatal intensive care and haematology units.
Citation
Barac , A , Cevik , M , Colovic , N , Lekovic , D , Stevanovic , G , Micic , J & Rubino , S 2020 , ' Investigation of a healthcare associated Candida tropicalis candidiasis cluster in a haematology unit and a systematic review of nosocomial outbreaks ' , Mycoses , vol. Early View . https://doi.org/10.1111/myc.13048
Publication
Mycoses
Status
Peer reviewed
DOI
https://doi.org/10.1111/myc.13048
ISSN
0933-7407
Type
Journal item
Rights
Copyright © 2020 Blackwell Verlag GmbH. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1111/myc.13048
Description
Dr Aleksandra Barac received support for research from the Project of Ministry of Education, Science and Technology of the Republic of Serbia (No. III45005).
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/21336

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

Advanced Search

Browse

All of RepositoryCommunities & CollectionsBy Issue DateNamesTitlesSubjectsClassificationTypeFunderThis CollectionBy Issue DateNamesTitlesSubjectsClassificationTypeFunder

My Account

Login

Open Access

To find out how you can benefit from open access to research, see our library web pages and Open Access blog. For open access help contact: openaccess@st-andrews.ac.uk.

Accessibility

Read our Accessibility statement.

How to submit research papers

The full text of research papers can be submitted to the repository via Pure, the University's research information system. For help see our guide: How to deposit in Pure.

Electronic thesis deposit

Help with deposit.

Repository help

For repository help contact: Digital-Repository@st-andrews.ac.uk.

Give Feedback

Cookie policy

This site may use cookies. Please see Terms and Conditions.

Usage statistics

COUNTER-compliant statistics on downloads from the repository are available from the IRUS-UK Service. Contact us for information.

© University of St Andrews Library

University of St Andrews is a charity registered in Scotland, No SC013532.

  • Facebook
  • Twitter