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Halogenated tryptophan derivatives disrupt essential transamination mechanisms in bloodstream form Trypanosoma brucei
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dc.contributor.author | Cockram, Peter E. | |
dc.contributor.author | Dickie, Emily A. | |
dc.contributor.author | Barrett, Michael P. | |
dc.contributor.author | Smith, Terry K. | |
dc.date.accessioned | 2020-12-21T11:30:09Z | |
dc.date.available | 2020-12-21T11:30:09Z | |
dc.date.issued | 2020-12-04 | |
dc.identifier | 271627529 | |
dc.identifier | 73ed5f55-6ac5-4eaa-aad2-656d006bb930 | |
dc.identifier | 000597154700002 | |
dc.identifier | 85098674990 | |
dc.identifier.citation | Cockram , P E , Dickie , E A , Barrett , M P & Smith , T K 2020 , ' Halogenated tryptophan derivatives disrupt essential transamination mechanisms in bloodstream form Trypanosoma brucei ' , PLoS Neglected Tropical Diseases , vol. 14 , no. 12 , e0008928 . https://doi.org/10.1371/journal.pntd.0008928 | en |
dc.identifier.issn | 1935-2735 | |
dc.identifier.other | crossref: 10.1371/journal.pntd.0008928 | |
dc.identifier.uri | https://hdl.handle.net/10023/21182 | |
dc.description | Funding for this work was provided by the University of St Andrews; EPSRC: EP/J500549/1 (TKS); University of Glasgow (MPB); BBSRC: BB/N007999/1 (MPB); Wellcome: 104111/Z/14/Z. | en |
dc.description.abstract | Amino acid metabolism within Trypanosoma brucei, the causative agent of human African trypanosomiasis, is critical for parasite survival and virulence. Of these metabolic processes, the transamination of aromatic amino acids is one of the most important. In this study, a series of halogenated tryptophan analogues were investigated for their anti-parasitic potency. Several of these analogues showed significant trypanocidal activity. Metabolomics analysis of compound-treated parasites revealed key differences occurring within aromatic amino acid metabolism, particularly within the widely reported and essential transamination processes of this parasite. | |
dc.format.extent | 19 | |
dc.format.extent | 2113283 | |
dc.language.iso | eng | |
dc.relation.ispartof | PLoS Neglected Tropical Diseases | en |
dc.subject | QR Microbiology | en |
dc.subject | RM Therapeutics. Pharmacology | en |
dc.subject | DAS | en |
dc.subject.lcc | QR | en |
dc.subject.lcc | RM | en |
dc.title | Halogenated tryptophan derivatives disrupt essential transamination mechanisms in bloodstream form Trypanosoma brucei | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | 10.1371/journal.pntd.0008928 | |
dc.description.status | Peer reviewed | en |
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