Halogenated tryptophan derivatives disrupt essential transamination mechanisms in bloodstream form Trypanosoma brucei
Date
04/12/2020Metadata
Show full item recordAbstract
Amino acid metabolism within Trypanosoma brucei, the causative agent of human African trypanosomiasis, is critical for parasite survival and virulence. Of these metabolic processes, the transamination of aromatic amino acids is one of the most important. In this study, a series of halogenated tryptophan analogues were investigated for their anti-parasitic potency. Several of these analogues showed significant trypanocidal activity. Metabolomics analysis of compound-treated parasites revealed key differences occurring within aromatic amino acid metabolism, particularly within the widely reported and essential transamination processes of this parasite.
Citation
Cockram , P E , Dickie , E A , Barrett , M P & Smith , T K 2020 , ' Halogenated tryptophan derivatives disrupt essential transamination mechanisms in bloodstream form Trypanosoma brucei ' , PLoS Neglected Tropical Diseases , vol. 14 , no. 12 , e0008928 . https://doi.org/10.1371/journal.pntd.0008928
Publication
PLoS Neglected Tropical Diseases
Status
Peer reviewed
ISSN
1935-2735Type
Journal article
Description
Funding for this work was provided by the University of St Andrews; EPSRC: EP/J500549/1 (TKS); University of Glasgow (MPB); BBSRC: BB/N007999/1 (MPB); Wellcome: 104111/Z/14/Z.Collections
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.