Persistent contaminants and herpesvirus OtHV1 are positively associated with cancer in wild California Sea Lions (Zalophus californianus)
MetadataShow full item record
Altmetrics Handle Statistics
Altmetrics DOI Statistics
The prevalence of cancer in wild California sea lions (Zalophus californianus) is one of the highest amongst mammals, with 18–23% of adult animals examined post-mortem over the past 40 years having urogenital carcinoma. To date, organochlorines, genotype and infection with Otarine herpesvirus-1 (OtHV-1) have been identified in separate studies using distinct animals as associated with this carcinoma. Multi-year studies using large sample sizes to investigate the relative importance of multiple factors on marine mammal health are rare due to logistical and ethical challenges. The objective of this study was to use a case control approach with samples from 394 animals collected over 20 years in a multifactorial analysis to explore the relative importance of distinct factors identified to date as associated with sea lion cancer in the likelihood of sea lion carcinoma. Stepwise regression indicated that the best model to explain carcinoma occurrence included herpesvirus status, contaminant exposure, and blubber depth, but not genotype at a single microsatellite locus, PV11. The odds of carcinoma was 43.57 times higher in sea lions infected with OtHV-1 (95% CI 14.61, 129.96, p <0.001), and 1.48 times higher for every unit increase in the loge[contaminant concentrations], ng g–1 (an approximate tripling of concentration), in their blubber (95% CI 1.11, 1.97, p <0.007), after controlling for the effect of blubber depth. These findings demonstrate the importance of contaminant exposure combined with OtHV1 infection, in the potential for cancer occurrence in wild sea lions.
Gulland , F M D , Hall , A J , Ylitalo , G M , Colegrove , K M , Norris , T , Duignan , P J , Halaska , B , Acevedo Whitehouse , K , Lowenstine , L J , Deming , A C & Rowles , T K 2020 , ' Persistent contaminants and herpesvirus OtHV1 are positively associated with cancer in wild California Sea Lions ( Zalophus californianus ) ' , Frontiers in Marine Science , vol. 7 , 602565 . https://doi.org/10.3389/fmars.2020.602565
Frontiers in Marine Science
Copyright © 2020 Gulland, Hall, Ylitalo, Colegrove, Norris, Duignan, Halaska, Acevedo Whitehouse, Lowenstine, Deming and Rowles. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.