Show simple item record

Files in this item


Item metadata

dc.contributor.authorMcQueenie, Ross
dc.contributor.authorNicholl, Barbara I
dc.contributor.authorJani, Bhautesh Dinesh
dc.contributor.authorCanning, Jordan
dc.contributor.authorMacdonald, Sara
dc.contributor.authorMcCowan, Colin
dc.contributor.authorNeary, Joanne
dc.contributor.authorBrowne, Susan
dc.contributor.authorMair, Frances S
dc.contributor.authorSiebert, Stefan
dc.identifier.citationMcQueenie , R , Nicholl , B I , Jani , B D , Canning , J , Macdonald , S , McCowan , C , Neary , J , Browne , S , Mair , F S & Siebert , S 2020 , ' Patterns of multimorbidity and their effects on adverse outcomes in rheumatoid arthritis : a study of 5658 UK Biobank participants ' , BMJ Open , vol. 10 , no. 11 , e038829 .
dc.identifier.otherPURE: 270328197
dc.identifier.otherPURE UUID: 46657d8f-b89e-4ce5-815d-6ec52eb3a041
dc.identifier.otherORCID: /0000-0002-9466-833X/work/85168526
dc.identifier.otherScopus: 85096817633
dc.identifier.otherWOS: 000604459900017
dc.descriptionFunding: This study was funded by Versus Arthritis (grant number 21970).en
dc.description.abstractObjective To investigate how the type and number of long-term conditions (LTCs) impact on all-cause mortality and major adverse cardiovascular events (MACE) in people with rheumatoid arthritis (RA). Design Population-based longitudinal cohort study. Setting UK Biobank. Participants UK Biobank participants (n=502 533) aged between 37 and 73 years old. Primary outcome measures Primary outcome measures were risk of all-cause mortality and MACE. Methods We examined the relationship between LTC count and individual comorbid LTCs (n=42) on adverse clinical outcomes in participants with self-reported RA (n=5658). Risk of all-cause mortality and MACE were compared using Cox’s proportional hazard models adjusted for lifestyle factors (smoking, alcohol intake, physical activity), demographic factors (sex, age, socioeconomic status) and rheumatoid factor. Results 75.7% of participants with RA had multimorbidity and these individuals were at increased risk of all-cause mortality and MACE. RA and >4 LTCs showed a threefold increased risk of all-cause mortality (HR 3.30, 95% CI 2.61 to 4.16), and MACE (HR 3.45, 95% CI 2.66 to 4.49) compared with those without LTCs. Of the comorbid LTCs studied, osteoporosis was most strongly associated with adverse outcomes in participants with RA compared with those without RA or LTCs: twofold increased risk of all-cause mortality (HR 2.20, 95% CI 1.55 to 3.12) and threefold increased risk of MACE (HR 3.17, 95% CI 2.27 to 4.64). These findings remained in a subset (n=3683) with RA diagnosis validated from clinical records or medication reports. Conclusion Those with RA and other LTCs, particularly comorbid osteoporosis, are at increased risk of adverse outcomes, although the role of corticosteroids could not be evaluated in this study. These results are clinically relevant for the monitoring and management of RA across the healthcare system, and future clinical guidelines for RA should acknowledge the importance of multimorbidity.
dc.relation.ispartofBMJ Openen
dc.rightsCopyright © Author(s) (or their employer(s)) 2020. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See:
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titlePatterns of multimorbidity and their effects on adverse outcomes in rheumatoid arthritis : a study of 5658 UK Biobank participantsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.description.statusPeer revieweden

This item appears in the following Collection(s)

Show simple item record