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dc.contributor.authorWest, Matthew
dc.contributor.authorFyfe, James
dc.contributor.authorVantourout, Julien C.
dc.contributor.authorWatson, Allan J. B.
dc.identifier.citationWest , M , Fyfe , J , Vantourout , J C & Watson , A J B 2019 , ' Mechanistic development and recent applications of the Chan–Lam amination ' , Chemical Reviews , vol. Articles ASAP .
dc.identifier.otherPURE: 263441530
dc.identifier.otherPURE UUID: 5aef9f79-26d6-4474-8345-a02bf163ac69
dc.identifier.otherScopus: 85075779035
dc.identifier.otherWOS: 000505627700008
dc.descriptionAuthors thank the University of St Andrews for a PhD studentship (MJW), the Leverhulme Trust for a postdoctoral fellowship (grant no.: RPG-2018-362; JWBF).en
dc.description.abstractTransition metal-mediated formation of C–N bonds is an essential synthetic methodology. The discovery of the Chan–Lam amination provided a C–N bond forming process that was mild, convenient, and inexpensive, offering an alternative to complementary methods using other transition metals (TMs). Over the past 20 years, this reaction has seen considerable development in its scope of application, uptake into industry, and understanding of its mechanism. This review provides an account of the development of the Chan–Lam amination, highlighting progress and notable examples of application since 2011. Focus is given to evolution in mechanistic understanding and selected applications of the methodology within medicinal and process chemistry.
dc.relation.ispartofChemical Reviewsen
dc.rightsCopyright © 2019 American Chemical Society. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at
dc.subjectQD Chemistryen
dc.titleMechanistic development and recent applications of the Chan–Lam aminationen
dc.typeJournal itemen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.description.statusPeer revieweden

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