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Mechanistic development and recent applications of the Chan–Lam amination

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Manuscript_AAM_.pdf (2.009Mb)
Date
22/11/2019
Author
West, Matthew
Fyfe, James
Vantourout, Julien C.
Watson, Allan J. B.
Keywords
QD Chemistry
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Abstract
Transition metal-mediated formation of C–N bonds is an essential synthetic methodology. The discovery of the Chan–Lam amination provided a C–N bond forming process that was mild, convenient, and inexpensive, offering an alternative to complementary methods using other transition metals (TMs). Over the past 20 years, this reaction has seen considerable development in its scope of application, uptake into industry, and understanding of its mechanism. This review provides an account of the development of the Chan–Lam amination, highlighting progress and notable examples of application since 2011. Focus is given to evolution in mechanistic understanding and selected applications of the methodology within medicinal and process chemistry.
Citation
West , M , Fyfe , J , Vantourout , J C & Watson , A J B 2019 , ' Mechanistic development and recent applications of the Chan–Lam amination ' , Chemical Reviews , vol. Articles ASAP . https://doi.org/10.1021/acs.chemrev.9b00491
Publication
Chemical Reviews
Status
Peer reviewed
DOI
https://doi.org/10.1021/acs.chemrev.9b00491
ISSN
0009-2665
Type
Journal item
Rights
Copyright © 2019 American Chemical Society. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1021/acs.chemrev.9b00491
Description
Authors thank the University of St Andrews for a PhD studentship (MJW), the Leverhulme Trust for a postdoctoral fellowship (grant no.: RPG-2018-362; JWBF).
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/21031

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