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A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverage

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dc.contributor.authorRussell, Clark D
dc.contributor.authorWhittaker, Ed
dc.contributor.authorDee, Dominic P
dc.contributor.authorFarquhar, Eilidh
dc.contributor.authorSaenz de Villaverde, Alba
dc.contributor.authorEvans, Morgan H
dc.contributor.authorLaurenson, Ian F
dc.contributor.authorMackintosh, Claire L
dc.contributor.authorCevik, Muge
dc.date.accessioned2020-10-29T15:30:10Z
dc.date.available2020-10-29T15:30:10Z
dc.date.issued2020-04-08
dc.identifier.citationRussell , C D , Whittaker , E , Dee , D P , Farquhar , E , Saenz de Villaverde , A , Evans , M H , Laurenson , I F , Mackintosh , C L & Cevik , M 2020 , ' A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverage ' , Clinical Infectious Diseases , vol. Advance Article , ciaa391 . https://doi.org/10.1093/cid/ciaa391en
dc.identifier.issn1058-4838
dc.identifier.otherPURE: 267370721
dc.identifier.otherPURE UUID: 10502cb5-1139-449f-892f-ebaa19be8935
dc.identifier.otherPubMed: 32266388
dc.identifier.otherORCID: /0000-0003-1133-3874/work/71955536
dc.identifier.otherWOS: 000606534600022
dc.identifier.otherScopus: 85100145070
dc.identifier.urihttps://hdl.handle.net/10023/20858
dc.descriptionC.D.R. is supported by an Edinburgh Clinical Academic Track (ECAT)/Wellcome Trust PhD Training Fellowship for Clinicians award (214178/Z/18/Z).en
dc.description.abstractAmong 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neutrophilia) and the absence of diabetes mellitus and prior doxycycline treatment (but not the time to HAP onset) identified patients not requiring broad-spectrum Gram-negative coverage.
dc.format.extent4
dc.language.isoeng
dc.relation.ispartofClinical Infectious Diseasesen
dc.rightsCopyright © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1093/cid/ciaa391.en
dc.subjectHospital-acquired pneumoniaen
dc.subjectGram-negative bacteriaen
dc.subjectDoxycyclineen
dc.subjectGentamicinen
dc.subjectAntimicrobial stewardshipen
dc.subjectQR Microbiologyen
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subject3rd-NDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQRen
dc.subject.lccRA0421en
dc.subject.lccRMen
dc.titleA sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverageen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Infection and Global Health Divisionen
dc.identifier.doihttps://doi.org/10.1093/cid/ciaa391
dc.description.statusPeer revieweden


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