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A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverage
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dc.contributor.author | Russell, Clark D | |
dc.contributor.author | Whittaker, Ed | |
dc.contributor.author | Dee, Dominic P | |
dc.contributor.author | Farquhar, Eilidh | |
dc.contributor.author | Saenz de Villaverde, Alba | |
dc.contributor.author | Evans, Morgan H | |
dc.contributor.author | Laurenson, Ian F | |
dc.contributor.author | Mackintosh, Claire L | |
dc.contributor.author | Cevik, Muge | |
dc.date.accessioned | 2020-10-29T15:30:10Z | |
dc.date.available | 2020-10-29T15:30:10Z | |
dc.date.issued | 2020-04-08 | |
dc.identifier | 267370721 | |
dc.identifier | 10502cb5-1139-449f-892f-ebaa19be8935 | |
dc.identifier | 32266388 | |
dc.identifier | 000606534600022 | |
dc.identifier | 85100145070 | |
dc.identifier.citation | Russell , C D , Whittaker , E , Dee , D P , Farquhar , E , Saenz de Villaverde , A , Evans , M H , Laurenson , I F , Mackintosh , C L & Cevik , M 2020 , ' A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverage ' , Clinical Infectious Diseases , vol. Advance Article , ciaa391 . https://doi.org/10.1093/cid/ciaa391 | en |
dc.identifier.issn | 1058-4838 | |
dc.identifier.other | ORCID: /0000-0003-1133-3874/work/71955536 | |
dc.identifier.uri | https://hdl.handle.net/10023/20858 | |
dc.description | C.D.R. is supported by an Edinburgh Clinical Academic Track (ECAT)/Wellcome Trust PhD Training Fellowship for Clinicians award (214178/Z/18/Z). | en |
dc.description.abstract | Among 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neutrophilia) and the absence of diabetes mellitus and prior doxycycline treatment (but not the time to HAP onset) identified patients not requiring broad-spectrum Gram-negative coverage. | |
dc.format.extent | 4 | |
dc.format.extent | 153414 | |
dc.language.iso | eng | |
dc.relation.ispartof | Clinical Infectious Diseases | en |
dc.subject | Hospital-acquired pneumonia | en |
dc.subject | Gram-negative bacteria | en |
dc.subject | Doxycycline | en |
dc.subject | Gentamicin | en |
dc.subject | Antimicrobial stewardship | en |
dc.subject | QR Microbiology | en |
dc.subject | RA0421 Public health. Hygiene. Preventive Medicine | en |
dc.subject | RM Therapeutics. Pharmacology | en |
dc.subject | 3rd-NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QR | en |
dc.subject.lcc | RA0421 | en |
dc.subject.lcc | RM | en |
dc.title | A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverage | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Infection and Global Health Division | en |
dc.identifier.doi | 10.1093/cid/ciaa391 | |
dc.description.status | Peer reviewed | en |
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