A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverage
Abstract
Among 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neutrophilia) and the absence of diabetes mellitus and prior doxycycline treatment (but not the time to HAP onset) identified patients not requiring broad-spectrum Gram-negative coverage.
Citation
Russell , C D , Whittaker , E , Dee , D P , Farquhar , E , Saenz de Villaverde , A , Evans , M H , Laurenson , I F , Mackintosh , C L & Cevik , M 2020 , ' A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverage ' , Clinical Infectious Diseases , vol. Advance Article , ciaa391 . https://doi.org/10.1093/cid/ciaa391
Publication
Clinical Infectious Diseases
Status
Peer reviewed
ISSN
1058-4838Type
Journal article
Rights
Copyright © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1093/cid/ciaa391.
Description
C.D.R. is supported by an Edinburgh Clinical Academic Track (ECAT)/Wellcome Trust PhD Training Fellowship for Clinicians award (214178/Z/18/Z).Collections
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.