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A retrospective cross-sectional study to determine chirality status of registered medicines in Tanzania
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dc.contributor.author | Mwamwitwa, Kissa W. | |
dc.contributor.author | Kaibere, Raphael M. | |
dc.contributor.author | Fimbo, Adam M. | |
dc.contributor.author | Sabitii, Wilber | |
dc.contributor.author | Ntinginya, Nyanda E. | |
dc.contributor.author | Mmbaga, Blandina T. | |
dc.contributor.author | Shewiyo, Danstan H. | |
dc.contributor.author | Shearer, Morven C. | |
dc.contributor.author | Smith, Andrew D. | |
dc.contributor.author | Kaale, Eliangiringa A. | |
dc.date.accessioned | 2020-10-21T10:30:02Z | |
dc.date.available | 2020-10-21T10:30:02Z | |
dc.date.issued | 2020-10-20 | |
dc.identifier | 270820175 | |
dc.identifier | 7c5768ad-c765-4e77-9e76-581e684736df | |
dc.identifier | 85093122732 | |
dc.identifier | 000585239000008 | |
dc.identifier.citation | Mwamwitwa , K W , Kaibere , R M , Fimbo , A M , Sabitii , W , Ntinginya , N E , Mmbaga , B T , Shewiyo , D H , Shearer , M C , Smith , A D & Kaale , E A 2020 , ' A retrospective cross-sectional study to determine chirality status of registered medicines in Tanzania ' , Scientific Reports , vol. 10 , no. 1 , 17834 . https://doi.org/10.1038/s41598-020-74932-x | en |
dc.identifier.issn | 2045-2322 | |
dc.identifier.other | RIS: urn:303CDB9C00209C587BE51582BED11A49 | |
dc.identifier.other | RIS: Mwamwitwa2020 | |
dc.identifier.other | ORCID: /0000-0002-2104-7313/work/82500863 | |
dc.identifier.other | ORCID: /0000-0002-9180-6928/work/82500872 | |
dc.identifier.other | ORCID: /0000-0002-4742-2791/work/82501126 | |
dc.identifier.uri | https://hdl.handle.net/10023/20806 | |
dc.description | Funding: European and Developing Countries Clinical Trials Partnership (EDCTP) under Streamlining Health Research Ethics Review and Regulatory Framework in Tanzania (SMERT) project. | en |
dc.description.abstract | Medicines with a stereogenic center (asymmetric carbon) are mainly present as racemates with a mixture of equal amounts of enantiomers. One enantiomer may be active while the other inactive, alternatively one may produce side-effects and even toxicity. However, there is lack of information on the chirality status (either racemates, single active enantiomer or achiral) of medicines circulated on the market particularly in African countries. We established the chirality status of registered medicines in Tanzania by conducting a retrospective cross-sectional study. Registration data for the past 15 years from 2003 to 2018 were extracted from TMDA-IMIS database to Microsoft excel for review and analysis. A total of 3,573 human medicines had valid registration. Out of which 2,150 (60%) were chiral and 1,423 (40%) achiral. Out of the chiral medicines, 1,591 (74%) and 559 (26%) were racemates and single active enantiomers, respectively. The proportion of racemates within chiral medicines was considerably higher than single enantiomer medicines. The use of racemates may cause harm to the public and may contribute to antimicrobial resistance due to potential existence of inactive and toxic enantiomers. In order to protect public health, regulatory bodies need to strengthen control of chiral medicines by conducting analysis of enantiomeric impurity. | |
dc.format.extent | 11 | |
dc.format.extent | 1386936 | |
dc.language.iso | eng | |
dc.relation.ispartof | Scientific Reports | en |
dc.subject | RA0421 Public health. Hygiene. Preventive Medicine | en |
dc.subject | RM Therapeutics. Pharmacology | en |
dc.subject | 3rd-DAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | RA0421 | en |
dc.subject.lcc | RM | en |
dc.title | A retrospective cross-sectional study to determine chirality status of registered medicines in Tanzania | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. Infection and Global Health Division | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews. St Andrews Sustainability Institute | en |
dc.contributor.institution | University of St Andrews. Education Division | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.identifier.doi | 10.1038/s41598-020-74932-x | |
dc.description.status | Peer reviewed | en |
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