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dc.contributor.authorMurawski, Caroline
dc.contributor.authorMischok, Andreas
dc.contributor.authorBooth, Jonathan Hunter
dc.contributor.authorKumar, Jothi Dinesh
dc.contributor.authorArcher, Emily
dc.contributor.authorTropf, Laura Christine
dc.contributor.authorKeum, Changmin
dc.contributor.authorDeng, Yali
dc.contributor.authorYoshida, Kou
dc.contributor.authorSamuel, Ifor David William
dc.contributor.authorSchubert, Marcel
dc.contributor.authorPulver, Stefan
dc.contributor.authorGather, Malte Christian
dc.date.accessioned2020-09-04T23:34:45Z
dc.date.available2020-09-04T23:34:45Z
dc.date.issued2019-09-05
dc.identifier.citationMurawski , C , Mischok , A , Booth , J H , Kumar , J D , Archer , E , Tropf , L C , Keum , C , Deng , Y , Yoshida , K , Samuel , I D W , Schubert , M , Pulver , S & Gather , M C 2019 , ' Narrowband organic light-emitting diodes for fluorescence microscopy and calcium imaging ' , Advanced Materials , vol. Early View . https://doi.org/10.1002/adma.201903599en
dc.identifier.issn0935-9648
dc.identifier.otherPURE: 260667582
dc.identifier.otherPURE UUID: 8e7e1df1-c40a-4743-a9da-77473ad67c8a
dc.identifier.otherORCID: /0000-0002-4857-5562/work/61622246
dc.identifier.otherORCID: /0000-0002-8739-4852/work/61622250
dc.identifier.otherORCID: /0000-0002-9995-6525/work/61622258
dc.identifier.otherORCID: /0000-0003-1086-0509/work/61622262
dc.identifier.otherORCID: /0000-0003-4725-7404/work/61622266
dc.identifier.otherScopus: 85071780752
dc.identifier.otherORCID: /0000-0001-5170-7522/work/69463416
dc.identifier.otherWOS: 000485331100001
dc.identifier.urihttp://hdl.handle.net/10023/20548
dc.descriptionFunding: Leverhulme Trust (RPG-2017-231), the EPSRC NSF-CBET lead agency agreement (EP/R010595/1, 1706207), the DARPA NESD program (N66001-17-C-4012) and the RS Macdonald Charitable Trust. C.M. acknowledges funding from the European Commission through a Marie Skłodowska Curie individual fellowship (703387). A.M. acknowledges funding through an individual fellowship of the Deutsche Forschungsgemeinschaft (404587082). Y.D. acknowledges support from the Chinese Scholarship Council (CSC). L.T. acknowledges studentship funding through the EPSRC CM-CDT (EP/L015110/1). M.S. acknowledges funding by the Royal Society (Dorothy Hodgkin Fellowship, DH160102).en
dc.description.abstractFluorescence imaging is an indispensable tool in biology, with applications ranging from single‐cell to whole‐animal studies and with live mapping of neuronal activity currently receiving particular attention. To enable fluorescence imaging at cellular scale in freely moving animals, miniaturized microscopes and lensless imagers are developed that can be implanted in a minimally invasive fashion; but the rigidity, size, and potential toxicity of the involved light sources remain a challenge. Here, narrowband organic light‐emitting diodes (OLEDs) are developed and used for fluorescence imaging of live cells and for mapping of neuronal activity in Drosophila melanogaster via genetically encoded Ca2+ indicators. In order to avoid spectral overlap with fluorescence from the sample, distributed Bragg reflectors are integrated onto the OLEDs to block their long‐wavelength emission tail, which enables an image contrast comparable to conventional, much bulkier mercury light sources. As OLEDs can be fabricated on mechanically flexible substrates and structured into arrays of cell‐sized pixels, this work opens a new pathway for the development of implantable light sources that enable functional imaging and sensing in freely moving animals.
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofAdvanced Materialsen
dc.rightsCopyright © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1002/adma.201903599en
dc.subjectCalcium imagingen
dc.subjectDistributed Bragg reflectoren
dc.subjectFluorescence microscopyen
dc.subjectOLEDen
dc.subjectQC Physicsen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectT Technologyen
dc.subjectDASen
dc.subject.lccQCen
dc.subject.lccRC0321en
dc.subject.lccTen
dc.titleNarrowband organic light-emitting diodes for fluorescence microscopy and calcium imagingen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews.Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews.Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.Condensed Matter Physicsen
dc.identifier.doihttps://doi.org/10.1002/adma.201903599
dc.description.statusPeer revieweden
dc.date.embargoedUntil2020-09-05


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