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Fluorine containing cyclopropanes : synthesis of aryl substituted all-cis 1,2,3-trifluorocylopropanes, a facially polar motif
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dc.contributor.author | Fang, Zeguo | |
dc.contributor.author | Cordes, David B. | |
dc.contributor.author | Slawin, Alexandra M. Z. | |
dc.contributor.author | O'Hagan, David | |
dc.date.accessioned | 2020-08-08T23:37:13Z | |
dc.date.available | 2020-08-08T23:37:13Z | |
dc.date.issued | 2019-09-14 | |
dc.identifier | 260562094 | |
dc.identifier | 12428270-33e7-47e2-ba32-9fade2c284b1 | |
dc.identifier | 85071618639 | |
dc.identifier | 000483700100006 | |
dc.identifier.citation | Fang , Z , Cordes , D B , Slawin , A M Z & O'Hagan , D 2019 , ' Fluorine containing cyclopropanes : synthesis of aryl substituted all- cis 1,2,3-trifluorocylopropanes, a facially polar motif ' , Chemical Communications , vol. 55 , no. 71 , pp. 10539-10542 . https://doi.org/10.1039/C9CC05749H | en |
dc.identifier.issn | 1359-7345 | |
dc.identifier.other | Bibtex: urn:b696f326f8c1c6926412b893cb0f5902 | |
dc.identifier.other | ORCID: /0000-0002-9527-6418/work/60630651 | |
dc.identifier.other | ORCID: /0000-0002-5366-9168/work/60630656 | |
dc.identifier.other | ORCID: /0000-0002-0510-5552/work/68281251 | |
dc.identifier.uri | https://hdl.handle.net/10023/20430 | |
dc.description | We thank the EPSRC for financial support (GR: EP/R013799/1) and we are grateful to the Chinese Scholarship Council (CSC) for Ph.D Studentship support (ZF). | en |
dc.description.abstract | The synthesis of substituted all-cis-1,2,3-trifluorocylopropanes are described for the first time. The three fluorines located on each of the cyclopropyl carbons with a stereochemistry where they are all on the same face of the cyclopropane, imparts a significant polarity to the molecule, and the inherent conformational rigidity and lowering of Log P makes this motif attractive for exploration as a substituent for pharmaceuticals and agrochemicals research. | |
dc.format.extent | 1123709 | |
dc.language.iso | eng | |
dc.relation.ispartof | Chemical Communications | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject.lcc | QD | en |
dc.title | Fluorine containing cyclopropanes : synthesis of aryl substituted all-cis 1,2,3-trifluorocylopropanes, a facially polar motif | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | 10.1039/C9CC05749H | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2020-08-09 | |
dc.identifier.grantnumber | EP/R013799/1 | en |
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