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Fluorine containing cyclopropanes : synthesis of aryl substituted all-cis 1,2,3-trifluorocylopropanes, a facially polar motif

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O_Hagan_2019_CC_Cyclopropanes_AAM.pdf (1.071Mb)
Date
14/09/2019
Author
Fang, Zeguo
Cordes, David B.
Slawin, Alexandra M. Z.
O'Hagan, David
Keywords
QD Chemistry
DAS
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Abstract
The synthesis of substituted all-cis-1,2,3-trifluorocylopropanes are described for the first time. The three fluorines located on each of the cyclopropyl carbons with a stereochemistry where they are all on the same face of the cyclopropane, imparts a significant polarity to the molecule, and the inherent conformational rigidity and lowering of Log P makes this motif attractive for exploration as a substituent for pharmaceuticals and agrochemicals research.
Citation
Fang , Z , Cordes , D B , Slawin , A M Z & O'Hagan , D 2019 , ' Fluorine containing cyclopropanes : synthesis of aryl substituted all- cis 1,2,3-trifluorocylopropanes, a facially polar motif ' , Chemical Communications , vol. 55 , no. 71 , pp. 10539-10542 . https://doi.org/10.1039/C9CC05749H
Publication
Chemical Communications
Status
Peer reviewed
DOI
https://doi.org/10.1039/C9CC05749H
ISSN
1359-7345
Type
Journal article
Rights
Copyright © 2019 The Author(s). This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1039/C9CC05749H
Description
We thank the EPSRC for financial support (GR: EP/R013799/1) and we are grateful to the Chinese Scholarship Council (CSC) for Ph.D Studentship support (ZF).
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/20430

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