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Uncovering the chemistry of C-C bond formation in C-nucleoside biosynthesis : crystal structure of a C -glycoside synthase/PRPP complex

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dc.contributor.authorGao, Sisi
dc.contributor.authorRadadiya, Ashish
dc.contributor.authorLi, Wenbo
dc.contributor.authorLiu, Huanting
dc.contributor.authorZhu, Wen
dc.contributor.authorDe Crécy-Lagard, Valérie
dc.contributor.authorRichards, Nigel G.J.
dc.contributor.authorNaismith, James H.
dc.date.accessioned2020-07-29T11:30:07Z
dc.date.available2020-07-29T11:30:07Z
dc.date.issued2020-07-14
dc.identifier269364238
dc.identifier8f9807d5-4b3b-4f87-b8b8-3ab2c3c4570a
dc.identifier85088012360
dc.identifier32515440
dc.identifier000547631500015
dc.identifier.citationGao , S , Radadiya , A , Li , W , Liu , H , Zhu , W , De Crécy-Lagard , V , Richards , N G J & Naismith , J H 2020 , ' Uncovering the chemistry of C-C bond formation in C-nucleoside biosynthesis : crystal structure of a C -glycoside synthase/PRPP complex ' , Chemical Communications , vol. 56 , no. 55 , pp. 7617-7620 . https://doi.org/10.1039/d0cc02834gen
dc.identifier.issn1359-7345
dc.identifier.urihttps://hdl.handle.net/10023/20359
dc.descriptionAuthors thank the Diamond Light Source for beam time allocation and beam line staff for assistance with data collection. Funding for these studies was provided by BBSRC (BB/T006161/1 & BB/T006188/1 to J. H. N. & N. G. J. R., respectively), and the National Institutes of Health (R01 GM129793 to V. d. C.-L.)en
dc.description.abstractThe enzyme ForT catalyzes C–C bond formation between 5′-phosphoribosyl-1′-pyrophosphate (PRPP) and 4-amino-1H-pyrazole-3,5-dicarboxylate to make a key intermediate in the biosynthesis of formycin A 5′-phosphate by Streptomyces kaniharaensis. We report the 2.5 Å resolution structure of the ForT/PRPP complex and locate active site residues critical for PRPP recognition and catalysis.
dc.format.extent4
dc.format.extent2794261
dc.language.isoeng
dc.relation.ispartofChemical Communicationsen
dc.subjectQD Chemistryen
dc.subjectCatalysisen
dc.subjectElectronic, Optical and Magnetic Materialsen
dc.subjectCeramics and Compositesen
dc.subjectChemistry(all)en
dc.subjectSurfaces, Coatings and Filmsen
dc.subjectMetals and Alloysen
dc.subjectMaterials Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleUncovering the chemistry of C-C bond formation in C-nucleoside biosynthesis : crystal structure of a C -glycoside synthase/PRPP complexen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1039/d0cc02834g
dc.description.statusPeer revieweden


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