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A structured population model of clonal selection in acute leukemias with multiple maturation stages

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1907.02842v1.pdf (2.920Mb)
Date
26/07/2019
Author
Lorenzi, Tommaso
Marciniak-Czochra, Anna
Stiehl, Thomas
Keywords
Acute Leukemia
Clonal selection
Continuously structured population models
Integro-differential equations
Asymptotic analysis
QA Mathematics
QH301 Biology
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
T-DAS
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Abstract
Recent progress in genetic techniques has shed light on the complex co-evolution of malignant cell clones in leukemias. However, several aspects of clonal selection still remain unclear. In this paper, we present a multi-compartmental continuously structured population model of selection dynamics in acute leukemias, which consists of a system of coupled integro-differential equations. Our model can be analysed in a more efficient way than classical models formulated in terms of ordinary differential equations. Exploiting the analytical tractability of this model, we investigate how clonal selection is shaped by the self-renewal fraction and the proliferation rate of leukemic cells at different maturation stages. We integrate analytical results with numerical solutions of a calibrated version of the model based on real patient data. In summary, our mathematical results formalise the biological notion that clonal selection is driven by the self-renewal fraction of leukemic stem cells and the clones that possess the highest value of this parameter are ultimately selected. Moreover, we demonstrate that the self-renewal fraction and the proliferation rate of non-stem cells do not have a substantial impact on clonal selection. Taken together, our results indicate that interclonal variability in the self-renewal fraction of leukemic stem cells provides the necessary substrate for clonal selection to act upon.
Citation
Lorenzi , T , Marciniak-Czochra , A & Stiehl , T 2019 , ' A structured population model of clonal selection in acute leukemias with multiple maturation stages ' , Journal of Mathematical Biology , vol. First Online . https://doi.org/10.1007/s00285-019-01404-w
Publication
Journal of Mathematical Biology
Status
Peer reviewed
DOI
https://doi.org/10.1007/s00285-019-01404-w
ISSN
0303-6812
Type
Journal article
Rights
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. This work has been made available online in accordance with the publisher's policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1007/s00285-019-01404-w
Description
Funding: TS and AM-C were supported by research funding from the German Research Foundation DFG (SFB 873; subproject B08). TL gratefully acknowledges support from the Heidelberg Graduate School (HGS).
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/20338

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