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Optical analysis of homocysteine metabolites using vibrational spectroscopy

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dc.contributor.authorChen, Mingzhou
dc.contributor.authorStrother, Lisa
dc.contributor.authorDoherty, Gayle Helane
dc.contributor.authorDholakia, Kishan
dc.date.accessioned2020-07-23T09:30:05Z
dc.date.available2020-07-23T09:30:05Z
dc.date.issued2020-07-15
dc.identifier268707910
dc.identifierff99170d-55dd-486f-b536-ad5ad4f90cc6
dc.identifier000550236700022
dc.identifier85105689161
dc.identifier.citationChen , M , Strother , L , Doherty , G H & Dholakia , K 2020 , ' Optical analysis of homocysteine metabolites using vibrational spectroscopy ' , OSA Continuum , vol. 3 , no. 7 , pp. 1958-1966 . https://doi.org/10.1364/OSAC.397780en
dc.identifier.issn2578-7519
dc.identifier.otherORCID: /0000-0003-3494-5857/work/77893684
dc.identifier.otherORCID: /0000-0002-6190-5167/work/77893741
dc.identifier.urihttps://hdl.handle.net/10023/20316
dc.descriptionFunding: Funding: European Union FAMOS project (FP7-ICT-317744); Engineering and Physical Sciences Research Council (EP/P030017/1); RS MacDonald Charitable Trust.en
dc.description.abstractHomocysteine (HCy) is a sulphur-containing amino acid that correlates with several maladaptive health conditions, including an enhanced risk of cardiovascular and neurodegenerative diseases. Detection of HCy and its potentially pathogenic metabolites are studied here for the first time, to the first of our knowledge, using Raman spectroscopy. This study shows that different HCy metabolites have distinct Raman spectra and that the limits of detection reach the sub-mM level for these compounds. This investigation paves the way for photonics–based approaches for detection of HCy–related fluids as predictive biomarkers of disease in blood, which would assist in early intervention for improved clinical outcomes.
dc.format.extent9
dc.format.extent521405
dc.language.isoeng
dc.relation.ispartofOSA Continuumen
dc.subjectQC Physicsen
dc.subjectRC Internal medicineen
dc.subjectT Technologyen
dc.subject3rd-DASen
dc.subject.lccQCen
dc.subject.lccRCen
dc.subject.lccTen
dc.titleOptical analysis of homocysteine metabolites using vibrational spectroscopyen
dc.typeJournal articleen
dc.contributor.sponsorEuropean Commissionen
dc.contributor.sponsorEPSRCen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1364/OSAC.397780
dc.description.statusPeer revieweden
dc.identifier.grantnumber317744en
dc.identifier.grantnumberEP/P030017/1en


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