Optical analysis of homocysteine metabolites using vibrational spectroscopy
Abstract
Homocysteine (HCy) is a sulphur-containing amino acid that correlates with several maladaptive health conditions, including an enhanced risk of cardiovascular and neurodegenerative diseases. Detection of HCy and its potentially pathogenic metabolites are studied here for the first time, to the first of our knowledge, using Raman spectroscopy. This study shows that different HCy metabolites have distinct Raman spectra and that the limits of detection reach the sub-mM level for these compounds. This investigation paves the way for photonics–based approaches for detection of HCy–related fluids as predictive biomarkers of disease in blood, which would assist in early intervention for improved clinical outcomes.
Citation
Chen , M , Strother , L , Doherty , G H & Dholakia , K 2020 , ' Optical analysis of homocysteine metabolites using vibrational spectroscopy ' , OSA Continuum , vol. 3 , no. 7 , pp. 1958-1966 . https://doi.org/10.1364/OSAC.397780
Publication
OSA Continuum
Status
Peer reviewed
ISSN
2578-7519Type
Journal article
Description
Funding: Funding: European Union FAMOS project (FP7-ICT-317744); Engineering and Physical Sciences Research Council (EP/P030017/1); RS MacDonald Charitable Trust.Collections
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