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Isothiourea-catalyzed synthesis of pyrrole- and indole-functionalized tetrasubstituted pyridines

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dc.contributor.authorZhang, Shuyue
dc.contributor.authorHartley, Will
dc.contributor.authorGreenhalgh, Mark David
dc.contributor.authorNg, Sean
dc.contributor.authorSlawin, Alexandra Martha Zoya
dc.contributor.authorSmith, Andrew David
dc.date.accessioned2020-07-22T11:30:02Z
dc.date.available2020-07-22T11:30:02Z
dc.date.issued2020-09-18
dc.identifier268531232
dc.identifier88e81d60-d67c-41ca-ab30-f52b8d5aabfd
dc.identifier000550781000001
dc.identifier85088313028
dc.identifier.citationZhang , S , Hartley , W , Greenhalgh , M D , Ng , S , Slawin , A M Z & Smith , A D 2020 , ' Isothiourea-catalyzed synthesis of pyrrole- and indole-functionalized tetrasubstituted pyridines ' , ChemCatChem , vol. 12 , no. 18 , pp. 4522-4525 . https://doi.org/10.1002/cctc.202000882en
dc.identifier.issn1867-3880
dc.identifier.otherORCID: /0000-0002-2104-7313/work/77893615
dc.identifier.otherORCID: /0000-0002-9527-6418/work/77893656
dc.identifier.urihttps://hdl.handle.net/10023/20307
dc.descriptionFunding: Engineering and Physical Sciences Research Council (Grant Number(s): EP/L016419/1); FP7 Ideas: European Research Council (Grant Number(s): 279850)en
dc.description.abstractThe generation of pyrrole- and indole-functionalized tetrasubstituted pyridines in a one-pot process from 2-(pyrrol-1-yl)acetic acid or 2-(indol-1-yl)acetic acid and α,β-unsaturated N-sulfonyl-ketimines is described. The process is proposed to operate via an isothiourea-catalyzed Michael addition-lactamization, followed by elimination of sulfinic acid and O-acylation to provide the final pyridine product.
dc.format.extent5
dc.format.extent3667688
dc.language.isoeng
dc.relation.ispartofChemCatChemen
dc.subjectAnnulationen
dc.subjectIsothioureaen
dc.subjectNitrogen heterocyclesen
dc.subjectOrganocatalysisen
dc.subjectPyridinesen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleIsothiourea-catalyzed synthesis of pyrrole- and indole-functionalized tetrasubstituted pyridinesen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorEuropean Commissionen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.identifier.doihttps://doi.org/10.1002/cctc.202000882
dc.description.statusPeer revieweden
dc.date.embargoedUntil2020-07-22
dc.identifier.grantnumberEP/L016419/1en
dc.identifier.grantnumberN/Aen


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