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Isothiourea-catalyzed synthesis of pyrrole- and indole-functionalized tetrasubstituted pyridines
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dc.contributor.author | Zhang, Shuyue | |
dc.contributor.author | Hartley, Will | |
dc.contributor.author | Greenhalgh, Mark David | |
dc.contributor.author | Ng, Sean | |
dc.contributor.author | Slawin, Alexandra Martha Zoya | |
dc.contributor.author | Smith, Andrew David | |
dc.date.accessioned | 2020-07-22T11:30:02Z | |
dc.date.available | 2020-07-22T11:30:02Z | |
dc.date.issued | 2020-09-18 | |
dc.identifier | 268531232 | |
dc.identifier | 88e81d60-d67c-41ca-ab30-f52b8d5aabfd | |
dc.identifier | 000550781000001 | |
dc.identifier | 85088313028 | |
dc.identifier.citation | Zhang , S , Hartley , W , Greenhalgh , M D , Ng , S , Slawin , A M Z & Smith , A D 2020 , ' Isothiourea-catalyzed synthesis of pyrrole- and indole-functionalized tetrasubstituted pyridines ' , ChemCatChem , vol. 12 , no. 18 , pp. 4522-4525 . https://doi.org/10.1002/cctc.202000882 | en |
dc.identifier.issn | 1867-3880 | |
dc.identifier.other | ORCID: /0000-0002-2104-7313/work/77893615 | |
dc.identifier.other | ORCID: /0000-0002-9527-6418/work/77893656 | |
dc.identifier.uri | https://hdl.handle.net/10023/20307 | |
dc.description | Funding: Engineering and Physical Sciences Research Council (Grant Number(s): EP/L016419/1); FP7 Ideas: European Research Council (Grant Number(s): 279850) | en |
dc.description.abstract | The generation of pyrrole- and indole-functionalized tetrasubstituted pyridines in a one-pot process from 2-(pyrrol-1-yl)acetic acid or 2-(indol-1-yl)acetic acid and α,β-unsaturated N-sulfonyl-ketimines is described. The process is proposed to operate via an isothiourea-catalyzed Michael addition-lactamization, followed by elimination of sulfinic acid and O-acylation to provide the final pyridine product. | |
dc.format.extent | 5 | |
dc.format.extent | 3667688 | |
dc.language.iso | eng | |
dc.relation.ispartof | ChemCatChem | en |
dc.subject | Annulation | en |
dc.subject | Isothiourea | en |
dc.subject | Nitrogen heterocycles | en |
dc.subject | Organocatalysis | en |
dc.subject | Pyridines | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject.lcc | QD | en |
dc.title | Isothiourea-catalyzed synthesis of pyrrole- and indole-functionalized tetrasubstituted pyridines | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | European Commission | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.identifier.doi | 10.1002/cctc.202000882 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2020-07-22 | |
dc.identifier.grantnumber | EP/L016419/1 | en |
dc.identifier.grantnumber | N/A | en |
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