Isothiourea-catalyzed synthesis of pyrrole- and indole-functionalized tetrasubstituted pyridines
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The generation of pyrrole- and indole-functionalized tetrasubstituted pyridines in a one-pot process from 2-(pyrrol-1-yl)acetic acid or 2-(indol-1-yl)acetic acid and α,β-unsaturated N-sulfonyl-ketimines is described. The process is proposed to operate via an isothiourea-catalyzed Michael addition-lactamization, followed by elimination of sulfinic acid and O-acylation to provide the final pyridine product.
Zhang , S , Hartley , W , Greenhalgh , M D , Ng , S , Slawin , A M Z & Smith , A D 2020 , ' Isothiourea-catalyzed synthesis of pyrrole- and indole-functionalized tetrasubstituted pyridines ' , ChemCatChem , vol. 12 , no. 18 , pp. 4522-4525 . https://doi.org/10.1002/cctc.202000882
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DescriptionFunding: Engineering and Physical Sciences Research Council (Grant Number(s): EP/L016419/1); FP7 Ideas: European Research Council (Grant Number(s): 279850)
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