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dc.contributor.authorDivala, Titus H
dc.contributor.authorFielding, Katherine L
dc.contributor.authorKandulu, Chikondi
dc.contributor.authorNliwasa, Marriott
dc.contributor.authorSloan, Derek James
dc.contributor.authorGupta-Wright, Ankur
dc.contributor.authorCorbett, Elizabeth L
dc.identifier.citationDivala , T H , Fielding , K L , Kandulu , C , Nliwasa , M , Sloan , D J , Gupta-Wright , A & Corbett , E L 2020 , ' Utility of broad-spectrum antibiotics for diagnosing pulmonary tuberculosis in adults : a systematic review and meta-analysis ' , Lancet Infectious Diseases , vol. 20 , no. 9 , pp. 1089-1098 .
dc.identifier.otherPURE: 268079447
dc.identifier.otherPURE UUID: 3369e4d3-9228-402d-914b-9e6e23514196
dc.identifier.otherScopus: 85085708127
dc.identifier.otherWOS: 000566754000052
dc.identifier.otherORCID: /0000-0002-7888-5449/work/74510333
dc.descriptionFunding: Helse Nord RHF, Wellcome Trust, and the UK Commonwealth Scholarship Commission.en
dc.description.abstractSuboptimal diagnostics for pulmonary tuberculosis drive the use of the so-called trial of antibiotics, a course of broad-spectrum antibiotics without activity against Mycobacterium tuberculosis that is given to patients who are mycobacteriology negative but symptomatic, with the aim of distinguishing pulmonary tuberculosis from bacterial lower respiratory tract infection. The underlying assumption—that patients with lower respiratory tract infection will improve, whereas those with pulmonary tuberculosis will not—has an unclear evidence base for such a widely used intervention (at least 26·5 million courses are prescribed per year). We aimed to collate available evidence on the diagnostic performance of the trial of antibiotics.
dc.relation.ispartofLancet Infectious Diseasesen
dc.rightsCopyright © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.en
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleUtility of broad-spectrum antibiotics for diagnosing pulmonary tuberculosis in adults : a systematic review and meta-analysisen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Infection and Global Health Divisionen
dc.description.statusPeer revieweden

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