Utility of broad-spectrum antibiotics for diagnosing pulmonary tuberculosis in adults : a systematic review and meta-analysis
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Suboptimal diagnostics for pulmonary tuberculosis drive the use of the so-called trial of antibiotics, a course of broad-spectrum antibiotics without activity against Mycobacterium tuberculosis that is given to patients who are mycobacteriology negative but symptomatic, with the aim of distinguishing pulmonary tuberculosis from bacterial lower respiratory tract infection. The underlying assumption—that patients with lower respiratory tract infection will improve, whereas those with pulmonary tuberculosis will not—has an unclear evidence base for such a widely used intervention (at least 26·5 million courses are prescribed per year). We aimed to collate available evidence on the diagnostic performance of the trial of antibiotics.
Divala , T H , Fielding , K L , Kandulu , C , Nliwasa , M , Sloan , D J , Gupta-Wright , A & Corbett , E L 2020 , ' Utility of broad-spectrum antibiotics for diagnosing pulmonary tuberculosis in adults : a systematic review and meta-analysis ' , Lancet Infectious Diseases , vol. 20 , no. 9 , pp. 1089-1098 . https://doi.org/10.1016/S1473-3099(20)30143-2
Lancet Infectious Diseases
Copyright © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
DescriptionFunding: Helse Nord RHF, Wellcome Trust, and the UK Commonwealth Scholarship Commission.
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