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A consecutive process for C–C and C–N bond formation with high enantio-and diastereocontrol : direct reductive amination of chiral ketones using hydrogenation catalysts

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dc.contributor.authorGilbert, Sophie H.
dc.contributor.authorViseur, Virginie
dc.contributor.authorClarke, Matthew L.
dc.date.accessioned2020-05-10T05:07:20Z
dc.date.available2020-05-10T05:07:20Z
dc.date.issued2019-06-07
dc.identifier259049136
dc.identifier7014ad21-2fc6-485b-be12-f55512fdd12f
dc.identifier85066436488
dc.identifier000471038300012
dc.identifier.citationGilbert , S H , Viseur , V & Clarke , M L 2019 , ' A consecutive process for C–C and C–N bond formation with high enantio-and diastereocontrol : direct reductive amination of chiral ketones using hydrogenation catalysts ' , Chemical Communications , vol. 55 , no. 45 , pp. 6409-6412 . https://doi.org/10.1039/c9cc00923jen
dc.identifier.issn1359-7345
dc.identifier.otherORCID: /0000-0002-2444-1244/work/59464624
dc.identifier.urihttps://hdl.handle.net/10023/19907
dc.descriptionAuthors thank the University of St Andrews, and the EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT) for financial support [PhD studentship to SG; Grant code: EP/L016419/1].en
dc.description.abstractHigh diastereoselectivity was observed in the Rh-catalysed reductive amination of 3-arylcyclohexanones to form tertiary amines. This was incorporated into a one-pot enantioselective conjugate addition and diastereoselective reductive amination, including an example of assisted tandem catalysis.
dc.format.extent4
dc.format.extent516550
dc.language.isoeng
dc.relation.ispartofChemical Communicationsen
dc.subjectAsymmetric hydrogenationen
dc.subjectReductive aminationen
dc.subjectHomogeneous catalysisen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleA consecutive process for C–C and C–N bond formation with high enantio-and diastereocontrol : direct reductive amination of chiral ketones using hydrogenation catalystsen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1039/c9cc00923j
dc.description.statusPeer revieweden
dc.date.embargoedUntil2020-05-10
dc.identifier.grantnumberEP/L016419/1en


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