A consecutive process for C–C and C–N bond formation with high enantio-and diastereocontrol : direct reductive amination of chiral ketones using hydrogenation catalysts

Thumbnail
View/Open
Diastereoredamacceptedversionpdf.pdf (504.4Kb)
Date
07/06/2019
Author
Funder
Grant ID
EP/L016419/1
Keywords
DAS
Metadata
Show full item record
Abstract
High diastereoselectivity was observed in the Rh-catalysed reductive amination of 3-arylcyclohexanones to form tertiary amines. This was incorporated into a one-pot enantioselective conjugate addition and diastereoselective reductive amination, including an example of assisted tandem catalysis.
Citation
Gilbert , S H , Viseur , V & Clarke , M L 2019 , ' A consecutive process for C–C and C–N bond formation with high enantio-and diastereocontrol : direct reductive amination of chiral ketones using hydrogenation catalysts ' , Chemical Communications , vol. 55 , no. 45 , pp. 6409-6412 . https://doi.org/10.1039/c9cc00923j
Publication
Chemical Communications
Status
Peer reviewed
DOI
https://doi.org/10.1039/c9cc00923j
ISSN
1359-7345
Type
Journal article
Rights
Copyright © 2019 The Author(s). This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1039/C9CC00923J
Description
Authors thank the University of St Andrews, and the EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT) for financial support [PhD studentship to SG; Grant code: EP/L016419/1].
Collections
URI
http://hdl.handle.net/10023/19907

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.