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dc.contributor.authorKar, Sayan
dc.contributor.authorRauch, Michael
dc.contributor.authorKumar, Amit
dc.contributor.authorLeitus, Gregory
dc.contributor.authorBen-David, Yehoshoa
dc.contributor.authorMilstein, David
dc.date.accessioned2020-04-28T10:30:02Z
dc.date.available2020-04-28T10:30:02Z
dc.date.issued2020-05-15
dc.identifier.citationKar , S , Rauch , M , Kumar , A , Leitus , G , Ben-David , Y & Milstein , D 2020 , ' Selective room-temperature hydrogenation of amides to amines and alcohols catalyzed by a ruthenium pincer complex and mechanistic insight ' , ACS Catalysis , vol. 10 , no. 10 , pp. 5511-5515 . https://doi.org/10.1021/acscatal.0c01406en
dc.identifier.issn2155-5435
dc.identifier.otherPURE: 267665877
dc.identifier.otherPURE UUID: 20c53fd5-ce36-4fcf-98fa-85374f6bf89f
dc.identifier.otherORCID: /0000-0002-8175-8221/work/73293765
dc.identifier.otherScopus: 85087943492
dc.identifier.urihttp://hdl.handle.net/10023/19862
dc.descriptionThis research was supported by the European Research Council (ERC AdG 692775). D.M. holds the Israel Matz Professorial Chair of Organic Chemistry. S.K. acknowledges the Sustainability and Energy Research Initiative (SAERI) of the Weizmann Institute of Science for a research fellowship. M.R. acknowledges the Zuckerman STEM Leadership Program for a research fellowship.en
dc.description.abstractWe report a room-temperature protocol for the hydrogenation of various amides to produce amines and alcohols. Compared with most previous reports for this transformation, which use high temperatures (typically, 100–200 °C) and H2 pressures (10–100 bar), this system proceeds under extremely mild conditions (RT, 5–10 bar of H2). The hydrogenation is catalyzed by well-defined ruthenium-PNNH pincer complexes (0.5 mol %) with potential dual modes of metal–ligand cooperation. An unusual Ru-amidate complex was formed and crystallographically characterized. Mechanistic investigations indicate that the room-temperature hydrogenation proceeds predominantly via the Ru–N amido/amine metal–ligand cooperation.
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofACS Catalysisen
dc.rightsCopyright © 2020 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.en
dc.subjectAmideen
dc.subjectHydrogenationen
dc.subjectMetal-ligand cooperationen
dc.subjectRuthenium-pinceren
dc.subjectRoom-tempatureen
dc.subjectRuthenium amidate complexen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleSelective room-temperature hydrogenation of amides to amines and alcohols catalyzed by a ruthenium pincer complex and mechanistic insighten
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.identifier.doihttps://doi.org/10.1021/acscatal.0c01406
dc.description.statusPeer revieweden


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